Mechanism of asymmetric ovarian development in chick embryos
| Autor: | Roshantha A.S. Chandraratna, Kiyotaka Toshimori, Hidefumi Yoshioka, Yuko Katoh-Fukui, Ken Ichirou Morohashi, Mamiko Maekawa, Yoshiyasu Ishimaru, Tomoko Komatsu, Hidesato Ogawa, Megumi Kasahara, Yoshiro Toyama |
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| Rok vydání: | 2008 |
| Předmět: |
endocrine system
medicine.medical_specialty Gonad medicine.drug_class Tretinoin Chick Embryo Biology Steroidogenic Factor 1 Models Biological Cyclin D1 Cytochrome P-450 Enzyme System Downregulation and upregulation Internal medicine medicine Animals Primordium Molecular Biology Body Patterning Cell Proliferation Homeodomain Proteins Regulation of gene expression Ovary Estrogen Receptor alpha Gene Expression Regulation Developmental Retinoic Acid 4-Hydroxylase Sex Determination Processes Cell biology medicine.anatomical_structure Endocrinology Nuclear receptor Estrogen Female Estrogen receptor alpha Signal Transduction Transcription Factors Developmental Biology |
| Zdroj: | Development. 135:677-685 |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.012856 |
| Popis: | In most animals, the gonads develop symmetrically, but most birds develop only a left ovary. A possible role for estrogen in this asymmetric ovarian development has been proposed in the chick, but the mechanism underlying this process is largely unknown. Here, we identify the molecular mechanism responsible for this ovarian asymmetry. Asymmetric PITX2 expression in the left presumptive gonad leads to the asymmetric expression of the retinoic-acid (RA)-synthesizing enzyme, RALDH2, in the right presumptive gonad. Subsequently, RA suppresses expression of the nuclear receptors Ad4BP/SF-1 and estrogen receptor α in the right ovarian primordium. Ad4BP/SF-1 expressed in the left ovarian primordium asymmetrically upregulates cyclin D1 to stimulate cell proliferation. These data suggest that early asymmetric expression of PITX2 leads to asymmetric ovarian development through up- or downregulation of RALDH2,Ad4BP/SF-1, estrogen receptor α and cyclin D1. |
| Databáze: | OpenAIRE |
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