Vitis vinifera L. Grape Skin Extract Prevents Development of Hypertension and Altered Lipid Profile in Spontaneously Hypertensive Rats: Role of Oxidative Stress
| Autor: | Dayane Teixeira Ognibene, Giselle França da Costa, Graziele Freitas de Bem, Michelle Teixeira Teixeira, Viviane da Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Angela Castro Resende, Anibal Sanchez Moura, Roberto Soares de Moura |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty hypertension Antioxidant medicine.medical_treatment Oxidative phosphorylation 030204 cardiovascular system & hematology medicine.disease_cause Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine TBARS oxidative stress cardiovascular diseases Kidney Nutrition and Dietetics Triglyceride medicine.diagnostic_test business.industry grape skin extract musculoskeletal system 030104 developmental biology Endocrinology medicine.anatomical_structure Blood pressure chemistry cardiovascular system spontaneously hypertensive rats business Lipid profile Oxidative stress circulatory and respiratory physiology Food Science |
| Zdroj: | Preventive Nutrition and Food Science |
| ISSN: | 2287-8602 2287-1098 |
| DOI: | 10.3746/pnf.2020.25.1.25 |
| Popis: | This study investigated the protective effect of a Vitis vinifera L. grape skin extract (ACH09) on blood pressure, lipid profile, and oxidative status in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP), total cholesterol, triglyceride, and glucose levels, as well as oxidative damage and antioxidant activity in the plasma and kidney, were evaluated in four experimental groups: control Wistar rats (W-C) and SHR-C that received water, and Wistar rats and SHR treated with ACH09 (200 mg/kg/d) in drinking water for 12 weeks (W-ACH09 and SHR-ACH09, respectively). SBP increased in the SHR group compared with the W groups and the treatment with ACH09 prevented the development of hypertension. Plasma triglyceride and total cholesterol levels increased in SHR compared with W-C rats; these changes prevented by treatment with ACH09. Glucose levels did not differ between the groups. The SHR group had increased oxidative damage in plasma, as expressed by 2-thiobarbituric acid reactive substances (TBARS) levels, and this prevented by ACH09. Levels of TBARS in the kidneys were lower in the SHR-ACH09 group than in the SHR-C group. Further, ACH09 increased the superoxide dismutase activity in both the plasma and kidneys of both SHR and Wistar rats. These results suggest that ACH09 is protective against disruption of blood pressures, oxidant status, and lipid profile in SHR, and provide important evidence on the benefits of ACH09 on hypertension and associated cardiovascular complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|