CUEDC2: multifunctional roles in carcinogenesis
| Autor: | Jun-bo Xiao, Guan-Nan Ye, Aimin Leng, Zhen Wen, Jian He, Yan-Qiu Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Carcinoma Hepatocellular Lung Neoplasms Carcinogenesis Mitosis Breast Neoplasms Biology Adenocarcinoma medicine.disease_cause Cholangiocarcinoma 03 medical and health sciences Mice 0302 clinical medicine Ovarian carcinoma Glioma medicine Carcinoma Animals Humans Adaptor Proteins Signal Transducing Regulation of gene expression Inflammation Ovarian Neoplasms Brain Neoplasms Gene Expression Profiling Macrophages Cell Cycle Liver Neoplasms NF-kappa B Membrane Proteins Cell cycle medicine.disease digestive system diseases Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female Signal transduction Carrier Proteins |
| Zdroj: | Frontiers in bioscience (Landmark edition). 24(5) |
| ISSN: | 2768-6698 |
| Popis: | The ubiquitously expressed multifunctional protein, CUEDC2 (CUE domain-containing 2), is involved in many physiological and pathological processes, including the cell cycle regulation and inflammation. Although it is known that CUEDC2 is expressed disparately in breast cancer, ovarian carcinoma, hepatocellular carcinoma, cholangiocarcinoma, glioma, lung adenocarcinoma, colon cancers, and is involved in the Warburg's effect, its role in oncogenesis remains to be further explored. In this review, we examine the expression of CUEDC2 in various tumors, and discuss several fundamental signaling pathways that are impacted by CUEDC2. |
| Databáze: | OpenAIRE |
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