Diverse developmental strategies of X chromosome dosage compensation in eutherian mammals
| Autor: | Irina S. Zakharova, E.V. Dementyeva, Alexander I. Shevchenko, S.M. Zakian |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Pluripotent Stem Cells Embryology X Chromosome Rodentia Biology X-inactivation Epigenesis Genetic Genomic Imprinting 03 medical and health sciences Downregulation and upregulation X Chromosome Inactivation Animals Gene silencing Gene Silencing Epigenetics X chromosome 030304 developmental biology Genetics 0303 health sciences Dosage compensation Up-Regulation Female RNA Long Noncoding XIST Genomic imprinting Developmental Biology |
| Zdroj: | The International Journal of Developmental Biology. 63:223-233 |
| ISSN: | 0214-6282 |
| DOI: | 10.1387/ijdb.180376as |
| Popis: | In eutherian mammals, dosage compensation arose to balance X-linked gene expression between sexes and relatively to autosomal gene expression in the evolution of sex chromosomes. Dosage compensation occurs in early mammalian development and comprises X chromosome upregulation and inactivation that are tightly coordinated epigenetic processes. Despite a uniform principle of dosage compensation, mechanisms of X chromosome inactivation and upregulation demonstrate a significant variability depending on sex, developmental stage, cell type, individual, and mammalian species. The review focuses on relationships between X chromosome inactivation and upregulation in mammalian early development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|