Early alterations of large-scale brain networks temporal dynamics in young children with autism
| Autor: | Aurélie Bochet, Martina Franchini, Marie Schaer, Reem Kais Jan, Christoph M. Michel, Tonia A. Rihs, Nada Kojovic, Holger Franz Sperdin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Brain development QH301-705.5 Autism Spectrum Disorder Electroencephalography behavioral disciplines and activities Article Ministate Neural Pathways mental disorders medicine Humans Biology (General) Default mode network Brain Mapping medicine.diagnostic_test Mechanism (biology) Functional connectivity Brain Infant Autism spectrum disorders medicine.disease EEG microstates Child Preschool Autism Female Psychology Neuroscience |
| Zdroj: | Communications Biology Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021) |
| Popis: | Autism spectrum disorders (ASD) are associated with disruption of large-scale brain network. Recently, we found that directed functional connectivity alterations of social brain networks are a core component of atypical brain development at early developmental stages in ASD. Here, we investigated the spatio-temporal dynamics of whole-brain neuronal networks at a subsecond scale in 113 toddlers and preschoolers (66 with ASD) using an EEG microstate approach. We first determined the predominant microstates using established clustering methods. We identified five predominant microstate (labeled as microstate classes A–E) with significant differences in the temporal dynamics of microstate class B between the groups in terms of increased appearance and prolonged duration. Using Markov chains, we found differences in the dynamic syntax between several maps in toddlers and preschoolers with ASD compared to their TD peers. Finally, exploratory analysis of brain–behavioral relationships within the ASD group suggested that the temporal dynamics of some maps were related to conditions comorbid to ASD during early developmental stages. To assess the association between Autism spectrum disorders (ASD) and the potential disruption of large-scale brain networks, Bochet, Sperdin et al investigated spatiotemporal dynamics of whole-brain neuronal networks in 113 toddlers and preschoolers (66 with ASD) using an EEG microstate approach. They found differences in the dynamic syntax between several maps in toddlers and pre-schoolers with ASD compared to their TD peers. |
| Databáze: | OpenAIRE |
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