Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations
| Autor: | Andrey Zharkikh, Thomas Bourgeron, Holly L. Boettger-Tong, Ken McElreavey, Alexander I. Agulnik, Colin E. Bishop |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Primates Mutation rate Genetic Linkage Biology Y chromosome Gene mapping Molecular evolution Y Chromosome Gene duplication Genetics Animals Humans Gene family Spermatogenesis Molecular Biology Gene Conserved Sequence Phylogeny Genetics (clinical) DNA Primers Polymorphism Genetic Base Sequence Models Genetic Genetic Variation RNA-Binding Proteins Cercopithecidae Deleted in Azoospermia 1 Protein General Medicine Biological Evolution Multigene Family Africa DNA Transposable Elements Y linkage Female |
| Zdroj: | Human Molecular Genetics. 7:1371-1377 |
| ISSN: | 1460-2083 |
| Popis: | The recent transposition to the Y chromosome of the autosomal DAZL1 gene, potentially involved in germ cell development, created a unique opportunity to study the rate of Y chromosome evolution and assess the selective forces that may act upon such genes, and provided a new estimate of the male-to-female mutation rate (alpham). Two different Y-located DAZ sequences were observed in all Old World monkeys, apes and humans. Different DAZ copies originate from independent amplification events in each primate lineage. A comparison of autosomal DAZL1 and Y-linked DAZ intron sequences gave a new figure for male-to-female mutation rates of alpham = 4. It was found that human DAZ exons and introns are evolving at the same rate, implying neutral genetic drift and the absence of any functional selective pressures. We therefore hypothesize that Y-linked DAZ plays little, or a limited, role in human spermatogenesis. The two copies of DAZ in man appear to be due to a relatively recent duplication event (55 000-200 000 years). A worldwide survey of 67 men from five continents representing 19 distinct populations showed that most males have both DAZ variants. This implies a common origin for the Y chromosome consistent with a recent 'out of Africa' origin of the human race. |
| Databáze: | OpenAIRE |
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