APRIL affects antibody responses and early leukocyte infiltration, but not influenza A viral control
| Autor: | Gijs Hardenberg, Tom van der Poll, Koen van der Sluijs, Jan Paul Medema |
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| Přispěvatelé: | Pulmonology, Experimental Immunology, Intensive Care Medicine, Amsterdam institute for Infection and Immunity, Infectious diseases, Cancer Center Amsterdam, Radiotherapy |
| Rok vydání: | 2008 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Transgene Tumor Necrosis Factor Ligand Superfamily Member 13 Immunology Cell Count CD8-Positive T-Lymphocytes Granulocyte Biology medicine.disease_cause Virus Microbiology Mice Antigens CD Cell Movement Immunity Leukocytes medicine Influenza A virus Animals Lectins C-Type Lung Molecular Biology Chemokine CCL2 B cell B-Lymphocytes Interleukin-6 Macrophages Body Weight T helper cell Viral Load Up-Regulation Mice Inbred C57BL medicine.anatomical_structure Immunoglobulin class switching Antibody Formation |
| Zdroj: | Molecular immunology, 45(11), 3050-3058. Elsevier Limited |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2008.03.017 |
| Popis: | A proliferation inducing ligand (APRIL) is implicated in the regulation of class switch recombination to IgA in T-independent B cell responses. Since B cells play an important role in the immunity to influenza A virus and resistance against the virus is partly controlled by T-independent IgA B cell responses, we studied the role of APRIL during an influenza A infection in vivo. APRIL transgenic, wild-type and APRIL deficient mice were intranasally infected with a non-lethal dose of a mouse adapted strain of influenza A. Compared to wild-type mice, APRIL deficient mice showed a twofold reduction in the amount of macrophages in the lungs and a tendency towards decreased granulocyte influx in the early leukocyte recruitment phase. Although the T cell immune response against influenza was unaffected, APRIL Tg mice showed prolonged influenza-specific IgM production and differential class switching. Unexpectedly, the IgA B cell response was completely T helper cell dependent and also not affected by the absence or presence of APRIL. In addition, viral clearance and recovery from the infection was not influenced by APRIL. Combined these results indicate that APRIL affects specific aspects of the anti-influenza response, but plays a limited role in disease recovery. |
| Databáze: | OpenAIRE |
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