An Ectopic ACTH-Producing Carcinoid Tumor Localized by the Measurement of ACTH in the Bronchial Lavage
| Autor: | Kunihide Hiramatsu, Mieko Kumagai, Kesami Minemura, Yasuto Ikeo, Kiyoshi Hashizume, Takeshi Inagaki, Wataru Yumita, Satoru Suzuki, Tpru Aizawa |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
endocrine system
medicine.medical_specialty Pathology Hydrocortisone Biopsy Endocrinology Diabetes and Metabolism Cushingoid Carcinoid Tumor Bronchial Lavage Diagnosis Differential Endocrinology Adrenocorticotropic Hormone Bronchoscopy Pituitary adenoma Internal medicine medicine Humans Cushing Syndrome Lung medicine.diagnostic_test business.industry Bronchial Neoplasms Ectopic acth Middle Aged medicine.disease ACTH Syndrome Ectopic medicine.anatomical_structure Ectopic ACTH syndrome Female business Bronchoalveolar Lavage Fluid hormones hormone substitutes and hormone antagonists Serum cortisol |
| Zdroj: | Endocrine Journal. 48:363-367 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.48.363 |
| Popis: | We report a case of an ectopic ACTH-producing carcinoid in the lung. Typical Cushingoid appearance, elevated plasma ACTH and serum cortisol, bilateral enlargement of the adrenal glands, absence of pituitary adenoma and negativity in petrosus sinus venous sampling indicated the ectopic ACTH syndrome. Venous samplings from a lung tumor which was detected by the chest X-ray, did not show any step-up of ACTH. However, ACTH concentration in the bronchoscopic lavage was as high as that in the peripheral blood. Removal of the tumor, which was an ACTH producing carcinoid, resulted in normalization of ACTH and cortisol concentrations. Measurement of ACTH in the bronchoscopic lavage was useful for the diagnosis of ectopic ACTH-producing tumor. |
| Databáze: | OpenAIRE |
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