Retinal thickness and microvascular alterations in the diagnosis of systemic lupus erythematosus: a new approach
Autor: | Tian Xu, Yan Wang, Ren Liu, Shuang Cai, Rui Wu, Ting Han, Shui-Lin Luo, Qiang Xia, Yi Shao |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Quant Imaging Med Surg |
ISSN: | 2223-4306 2223-4292 |
Popis: | BACKGROUND: To investigate the differences of retinal thickness (RT) and superficial vascular density (SVD) between patients with systemic lupus erythematosus (SLE) and healthy controls using optical coherence tomography angiography (OCTA). METHODS: Individuals with SLE (n=12; 24 eyes) and healthy controls (n=12; 24 eyes) were recruited to this study. The study protocol was in accordance with the tenets of the Declaration of Helsinki (as revised in 2013). The monocular best-corrected visual acuity (BCVA) was determined using a Snellen eye chart. Each image was segmented into 9 early treatment diabetic retinopathy study subregions, within which the macular RT and SVD were measured by OCTA. The vascular perfusion area as a percentage of the measured area was considered to be the vascular density. RESULTS: The mean age of the SLE group was 33.80±9.49 years, and the mean age of the control group was 33.20±9.41 years. The mean duration of SLE was 4.33±2.67 years. The BCVA was significantly different between the SLE and control groups (0.17±0.20 vs. 0.05±0.07, respectively; P=0.021). In the SLE group, inner RT was reduced in the outer superior and temporal regions and full RT was reduced in the outer temporal region, compared with the control group (P |
Databáze: | OpenAIRE |
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