Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on dose-adjusted plasma levels of carbamazepine in epileptic patients in South Indian population
| Autor: | Sunil K Narayan, Kesavan Ramasamy, Surendiran Adithan, Mahalakshmi Ganesapandian |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype 030226 pharmacology & pharmacy White People law.invention 03 medical and health sciences Young Adult 0302 clinical medicine genetic polymorphisms law Internal medicine medicine Cytochrome P-450 CYP3A Humans Pharmacology (medical) 030212 general & internal medicine CYP3A5 Child Genotyping Polymerase chain reaction pharmacogenetics Pharmacology Epilepsy Polymorphism Genetic cytochrome P450 3A5 Chemistry Carbamazepine Plasma levels Endocrinology Anticonvulsants South indian population Pharmacogenetics medicine.drug Research Article |
| Zdroj: | Indian Journal of Pharmacology |
| ISSN: | 1998-3751 |
| Popis: | AIM: The aim of the study was to compare the dose-adjusted plasma levels of carbamazepine (CBZ) among expressers and nonexpressers of cytochrome P450 3A5 (CYP3A5)* 3 genotypes. SUBJECTS AND METHODS: The study was carried out in 100 epileptic patients who were on CBZ monotherapy. Steady-state plasma CBZ levels were measured using reverse-phase high-performance liquid chromatography method, and genotyping of CYP3A5 was done using real-time polymerase chain reaction method. RESULTS: Patients inheriting CYP3A5*3/*3 variant (nonexpressers) had an increased plasma concentration of CBZ (4.86 μg/ml) when compared to patients inheriting either CYP3A5*1/*1 or CYP3A5*1/*3 (expressers) (4.3 μg/ml, P = 0.004). Nonexpressers had significantly increased plasma concentrations of CBZ when adjusted for dose and weight when compared to expressers (P < 0.002 and P < 0.001, respectively). The frequency of adverse reactions in expressers and nonexpressers was 12% and 9%, respectively. CONCLUSION: There is a significant influence of CYP3A5*3 genetic polymorphism (6986A>G) on dose-adjusted plasma levels of CBZ in epileptic patients in the South Indian population. |
| Databáze: | OpenAIRE |
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