Marine Algae of the Genus Gracilaria as Multi Products Source for Different Biotechnological and Medical Applications
| Autor: | Nehad M. Abd El-Moneam, Samy A. El-Assar, Asmaa Nabil-Adam, Mohamed A. Shreadah |
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| Rok vydání: | 2019 |
| Předmět: |
Aquatic Organisms
Antioxidant medicine.medical_treatment Phytochemicals Anti-Inflammatory Agents 010501 environmental sciences 01 natural sciences Applied Microbiology and Biotechnology Antioxidants Gracilaria Food science Selenium Compounds Carotenoid Nootropic Agents chemistry.chemical_classification 0303 health sciences biology Cytotoxins Fatty Acids Phytochemical visual_art visual_art.visual_art_medium Steroids Biotechnology Cell Survival Iron chemistry.chemical_element Bioengineering Patents as Topic 03 medical and health sciences Pigment Alkaloids Algae Cell Line Tumor medicine Humans 030304 developmental biology 0105 earth and related environmental sciences Biological Products Sulfur Compounds Pigments Biological biology.organism_classification Sulfur Antineoplastic Agents Phytogenic Carotenoids High-Throughput Screening Assays chemistry Selenium Copper |
| Zdroj: | Recent patents on biotechnology. 14(3) |
| ISSN: | 2212-4012 |
| Popis: | BACKGROUND Gracilaria has been shown to be an important source of marine bioactive natural biomaterials and compounds. Although there are no enough patents used Gracilaria worldwide, the current study tries to put the Gracilaria on the spot for further important patents in the future. OBJECTIVE The current study investigates the pharmaceuticals and biochemical activity of Gracilaria because no previous studies have been carried out to examine the biochemical and pharmaceutical activates of Gracilaria from the Suez Canal of Egypt as an excellent source for bioactive compounds. METHODS Different advanced experimental models and analytical techniques, such as cytotoxicity, total antioxidant capacity, anticancer, and anti-inflammatory profiling were applied. The phytochemical analysis of different constituents was also carried out. RESULTS The mineral analysis revealed the presence of copper (188.3 ppm) and iron (10.07 ppm) in addition to a remarkable wealth of selenium and sulfur contents giving up to 36% of its dry mass. The elemental analysis showed high contents of sulfur and nitrogen compounds. The GCMS profiling showed varieties of different bioactive compounds, such as fatty acids, different types of carotenoids in addition to pigments, alkaloids, steroids. Many other compounds, such as carbohydrates and amino acids having antioxidant, anti-inflammatory, and antiviral activities, etc. were identified. The cytotoxicity activity of Gracilaria marine extract was very effective against cancerous cell lines and showed high ability as a potent antitumor due to their bioactive constituents. Specialized screening assays using two anticancer experimental models, i.e., PTK and SKH1 revealed 77.88% and 84.50% inhibition anticancer activity; respectively. The anti-inflammatory activities investigated using four different experimental models, i.e., COX1, COX2, IL6, and TNF resulted in 68%, 81.76%, 56.02% and 78.43% inhibition; respectively. Moreover, Gracilaria extracts showed potent anti-Alzheimer with all concentrations. CONCLUSION Gracilaria proved to be a multi-product source of marine natural products for different biotechnological applications. Our recommendation is to investigate the Gracilaria bioactive secondary metabolites in order to create and innovate in more patents from current important seaweeds (Gracilaria). |
| Databáze: | OpenAIRE |
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