Genomic Encryption of Digital Data Stored in Synthetic DNA

Autor:	Robert N. Grass, Christophe Dessimoz, Reinhard Heckel, Wendelin J. Stark
Rok vydání:	2020
Předmět:	Massive parallel sequencing business.industry Computer science Digital data General Medicine Encryption DNA sequencing ComputingMethodologies_PATTERNRECOGNITION Strong cryptography Entropy (information theory) Microsatellite Human genome business Computer hardware
Zdroj:	Angewandte Chemie. 132:8554-8558
ISSN:	1521-3757 0044-8249
DOI:	10.1002/ange.202001162
Popis:	Today, we can read human genomes and store digital data robustly in synthetic DNA. Here we report a strategy to intertwine these two technologies to enable the secure storage of valuable information in synthetic DNA, protected with personalized keys. We show that genetic short tandem repeats (STRs) contain sufficient entropy to generate strong encryption keys, and that only one technology, DNA sequencing, is required to simultaneously read key and data. Using this approach, we experimentally generated 80 bit strong keys from human DNA, and used such a key to encrypt 17kB of digital information stored in synthetic DNA. Finally, the decrypted information was recovered perfectly from a single massively parallel sequencing run.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45c7a958c231ba37f85136fe117a6ff https://doi.org/10.1002/ange.202001162 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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