Association of TGFB1 gene polymorphisms with cervical cancer in Bangladeshi women: A case-control study
| Autor: | Mohd Nazmul Hasan Apu, Shaki Mostaid, Most. Nasrin Aktar, Morshadur Rahman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty Genotype Uterine Cervical Neoplasms Single-nucleotide polymorphism Polymorphism Single Nucleotide Transforming Growth Factor beta1 03 medical and health sciences 0302 clinical medicine Gene Frequency Polymorphism (computer science) Internal medicine Genetic predisposition Humans Medicine Genotyping Genetic Association Studies Cervical cancer Bangladesh business.industry Case-control study Cancer General Medicine Middle Aged medicine.disease 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female Gene polymorphism business |
| Zdroj: | Tumor Biology. 43:27-35 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.3233/tub-200061 |
| Popis: | OBJECTIVES: Genetic susceptibility to cervical cancer in relation to transforming growth factor beta 1 (TGFB1) gene polymorphisms has not been investigated extensively among the women in Bangladesh. So, the aim of this study was to find out the correlation of the polymorphisms of TGFB1 C509T (rs1800469) and T869C (rs1800470) with the risk of cervical cancer among the Bangladeshi women. STUDY DESIGN: 134 cervical cancer patients and 102 age-sex matched healthy controls were included from two institutions in Bangladesh. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping two TGFB1 single nucleotide polymorphisms C509T (rs1800469) and T869C (rs1800470) in patients and controls. RESULTS: No significant correlation was found between polymorphisms C509T (rs1800469) and T869C (rs1800470) of TGFB1 gene with cervical cancer in Bangladeshi women. In case of the cervical cancer patients who had first degree relatives with cancer were prone to carry the polymorphic version of the TGFB1 gene polymorphism at C509T (OR = 5.597, 95% CI = 1.224–25.597, p |
| Databáze: | OpenAIRE |
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