AIpha-1-Antitrypsin: The PiM Subtypes and Serum Concentrations in Finnish Newborns

Autor:	Kalevi Finni, Seppo Similä, Heikki Rantala
Rok vydání:	1982
Předmět:	Male Isoelectric focusing Infant Newborn Genetic Variation Pi phenotypes Serum concentration Biology Phenotype Gene Frequency alpha 1-Antitrypsin alpha 1-Antitrypsin Deficiency hemic and lymphatic diseases Immunology Genetics Humans Female Isoelectric Focusing Alleles Finland Genetics (clinical)
Zdroj:	Human Heredity. 32:228-232
ISSN:	1423-0062 0001-5652
DOI:	10.1159/000153298
Popis:	Pi phenotypes were classified by isoelectric focusing of the sera of 200 full-term Finnish newborns at the age of 3--5 days. The phenotype PiM was found in 95% of the neonates. The frequencies of the alleles PiM1, PiM2 and PiM3 were 0.682, 0.189 and 0.129, respectively. The serum concentration (mean +/- SD) of alpha-1-antitrypsin (alpha 1-AT) in the whole study group was 2.72 +/- 0.61 g/l. The concentration of alpha 1-AT in the newborns with the phenotype PiM3 (1.79 +/- 0.65 g/l) was significantly lower (p less than 0.025) than in other PiM subtypes. No difference in serum concentrations of alpha 1-AT between boys (2.78 +/- 0.66 g/l) and girls (2.66 +/- 0.55 g/l) was observed.
Databáze:	OpenAIRE
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