Temporal correlation between adenosine outflow and synaptic potential inhibition in rat hippocampal slices during ischemia-like conditions
| Autor: | Francesca Bordoni, Felicita Pedata, Serena Latini, Renato Corradetti, Giancarlo Pepeu |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Adenosine Time Factors Ischemia Hippocampus Hippocampal formation Neurotransmission In Vitro Techniques Synaptic Transmission Brain Ischemia Internal medicine medicine Animals Rats Wistar Molecular Biology Synaptic potential Chemistry General Neuroscience Excitatory Postsynaptic Potentials medicine.disease Rats Electrophysiology Endocrinology Excitatory postsynaptic potential Neurology (clinical) Neuroscience Developmental Biology medicine.drug |
| Zdroj: | Brain research. 794(2) |
| ISSN: | 0006-8993 |
| Popis: | The temporal correlation between adenosine outflow and changes in field excitatory post synaptic potentials (fEPSP) occurring during ischemia-like conditions was investigated in rat hippocampal slices. Five-minute long ischemia-like conditions resulted in a 100% depression of fEPSP amplitude, followed by a complete recovery after 6-7 min of reperfusion. By reducing the duration of the ischemic insult to 2 min, fEPSP was depressed by 50%. During both 5 and 2 min of ischemia-like conditions, a significant increase in adenosine outflow was detected. During reperfusion, when fEPSP amplitude recovered completely, the adenosine level in the extracellular fluid returned to basal values. The strict relationship between the increase in adenosine outflow and fEPSP inhibition supports the hypothesis that adenosine is largely responsible for the synaptic transmission depression during cerebral ischemia. |
| Databáze: | OpenAIRE |
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