Wave reflections, assessed with a novel method for pulse wave separation, are associated with end-organ damage and clinical outcomes
| Autor: | Siegfried Wassertheurer, Thomas Weber, Bernd Eber, Martin Rammer, A. Haiden, Bernhard Hametner |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pulse Wave Analysis End organ damage Manometry Pulsatile flow Myocardial Infarction Blood Pressure Kidney Predictive Value of Tests Risk Factors Internal medicine Internal Medicine Medicine Pulse wave Humans Myocardial infarction Prospective Studies Aorta Aged Retrospective Studies business.industry Heart Middle Aged medicine.disease Prognosis Pulse pressure Pulse (physics) Surgery Stroke Blood pressure Pulsatile Flow Hypertension Cardiology Female business Algorithms Blood Flow Velocity Follow-Up Studies |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 60(2) |
| ISSN: | 1524-4563 |
| Popis: | We recently developed a novel method for assessment of arterial wave reflections (ARCSolver method): based on adopted Windkessel methods, flow curves are estimated from pressure waveforms, and wave separation analysis is performed, yielding the amplitudes of the forward and backward waves. The aim of this study was to investigate their clinical correlates and prognostic impact. In 725 patients (417 men; mean age, 64 years) undergoing coronary angiography, we determined wave reflections from radial tonometry and transfer function-derived aortic waveforms using pulse wave analysis, as well as wave separation analysis. Measures of pulsatile arterial function were statistically significant, although moderately associated with markers of cardiac load and subclinic cardiac, renal, and aortic end-organ damage. After a median follow-up duration of 1399 days, 139 patients reached the combined cardiovascular end point (death, myocardial infarction, stroke, coronary, cerebrovascular, and peripheral revascularization). In univariate analysis, the relative risk of the combined end point increased with increasing levels of incident pressure wave height, augmented pressure, and forward and backward wave amplitude (hazard ratio for 1 SD was 1.302, 1.236, 1.226, and 1.276; P |
| Databáze: | OpenAIRE |
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