The effects of intravenous anesthetics on QT interval during anesthetic induction with desflurane
| Autor: | Makito Oji, Shigehiko Urabe, Makoto Fukusaki, Natsuko Oji, Maki Ono, Yoshiaki Terao, Shozo Tominaga, Tetsuya Hara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
QT interval
medicine.medical_treatment Fentanyl lcsh:RD78.3-87.3 03 medical and health sciences Desflurane 0302 clinical medicine 030202 anesthesiology Thiamylal medicine Intubation Rocuronium Propofol Clinical Research Article business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 Anesthesiology and Pain Medicine QT dispersion lcsh:Anesthesiology Bispectral index Anesthesia business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | JA Clinical Reports, Vol 4, Iss 1, Pp 1-6 (2018) JA Clinical Reports |
| ISSN: | 2363-9024 |
| DOI: | 10.1186/s40981-018-0195-9 |
| Popis: | Introduction This study aimed to determine the effects of the interaction between intravenous anesthetics and desflurane on the QT interval. Methods Fifty patients who underwent lumbar spine surgery were included. The patients received 3 μg/kg fentanyl and were randomly divided into two groups: group P patients received 1.5 mg/kg propofol and group T patients received 5 mg/kg thiamylal 2 min after fentanyl injection. All patients received rocuronium and desflurane (6% inhaled concentration) after loss of consciousness. Tracheal intubation was performed 3 min after rocuronium injection. Heart rate (HR), mean arterial pressure (MAP), bispectral index score (BIS), and the heart rate-corrected QT (QTc) interval on a 12-lead electrocardiograms were recorded before fentanyl injection (T1), 2 min after fentanyl injection (T2), 1 min after propofol or thiamylal injection (T3), immediately before intubation (T4), and 2 min after intubation (T5). Results There were no significant intergroup differences in patient characteristics. BIS and MAP decreased after anesthesia induction in both groups. MAP values at T3, T4, and T5 in group T were higher than those in group P. HR did not change over time or differ between the groups. The QTc intervals at T4 and T5 in group T were longer than those at T1. In group P, the QTc interval at T3 was significantly shorter than that at T1. The QTc intervals at T3, T4, and T5 in group T were significantly longer than those in group P. Conclusions A propofol injection could counteract the QTc interval prolongation during desflurane anesthesia induction. Trial registration UMIN Clinical Trials Registry database reference number: UMIN000023707. This study was registered on August 21, 2016. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink