Comprehensive Analysis of Factors Affecting Cochlear Size: A Systematic Review and Meta‐analysis
Autor: | Mahmut Tayyar Kalcioglu, Mehmet Bilgin Eser, Basak Atalay, Handan Ankarali |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Hearing Loss Sensorineural medicine.medical_treatment Population Audiology 03 medical and health sciences Sex Factors 0302 clinical medicine Cochlear implant otorhinolaryngologic diseases medicine Humans Congenital sensorineural hearing loss 030223 otorhinolaryngology education Cochlea Measurement method education.field_of_study business.industry Age Factors Organ Size Confidence interval medicine.anatomical_structure Otorhinolaryngology Organ of Corti Meta-analysis Female sense organs business 030217 neurology & neurosurgery |
Zdroj: | The Laryngoscope. 132:188-197 |
ISSN: | 1531-4995 0023-852X |
DOI: | 10.1002/lary.29532 |
Popis: | Objectives To determine the cochlea's average size in humans and evaluate the relationships between certain covariates and cochlear size. Methods A systematic search on articles on cochlear size and published in English was conducted using Cochrane, PubMed, Web of Science, and Scopus databases up to September 15, 2020. Data were pooled using random-effects with three models. The effect of demographic, clinical, and measurement-related parameters was specifically analyzed. Meta-regression and subgroup analyses were conducted. The overall effect estimation was made for outcomes. Results The meta-analysis included 4,708 cochleae from 56 studies. The overall length of the organ of Corti was 32.94 mm (95% confidence interval [CI]: 32.51-33.38). The first and second models revealed that age, gender, country, continent, measurement method (direct, indirect), measured structure ("A" value, cochlear lateral wall), origin (in vivo, in vitro), and type (histology specimens, plastic casts, imaging) of the cochlear material did not affect the cochlear size. However, study populations (general population, patients with a cochlear implant, and patients with congenital sensorineural hearing loss [CSNHL]) were found to affect the outcomes. Compared to the other populations, patients with CSNHL had shorter cochleae. Therefore, we developed a third model and found that the general population and patients with cochlear implants did not differ in cochlear size. Conclusion This meta-analysis investigated the factors that could affect the cochlear size and found that patients with CSNHL had significantly shorter cochleae, whereas other covariates had no significant effect. Laryngoscope, 2021. |
Databáze: | OpenAIRE |
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