Therapeutic efficacy of doxorubicin delivery by a CO2 generating liposomal platform in breast carcinoma
| Autor: | Ho Jin Kwon, Byung Cheol Shin, Yeongseon Byeon, Hat Nim Jeon, Chong Ock Lee, Ye Won Jeon, Hee Dong Han, Sun Hang Cho |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
media_common.quotation_subject Biomedical Engineering Mice Nude Breast Neoplasms Pharmacology Biochemistry Biomaterials Mice Breast cancer medicine Animals Humans Doxorubicin Molecular Biology Cancer media_common Tumor microenvironment Liposome business.industry General Medicine Carbon Dioxide medicine.disease Xenograft Model Antitumor Assays Targeted drug delivery Liposomes Drug delivery Female business Breast carcinoma Gas generation Biotechnology medicine.drug |
| Zdroj: | Acta Biomaterialia. 24:279-285 |
| ISSN: | 1742-7061 |
| DOI: | 10.1016/j.actbio.2015.06.019 |
| Popis: | Drug delivery using thermosensitive liposomes (TSL) has significant potential for tumor drug targeting and can be combined with local hyperthermia to trigger drug release. Although TSL-mediated drug delivery can be effective by itself, we developed doxorubicin (DOX)-containing CO2 bubble-generating TSL (TSL-C) that were found to enhance the antitumor effects of DOX owing to the synergism between burst release of drug and hyperthermia-induced CO2 generation. An ultrasound imaging system was used to monitor hyperthermia-induced CO2 generation in TSL-C and the results revealed that hyperthermia-induced CO2 generation in TSL-C led to increased DOX release compared to that observed for non-CO2-generating TSL. Moreover, TSL-C significantly inhibited the tumor growth in MDA-MB-231 tumor-bearing mice compared to TSL (p |
| Databáze: | OpenAIRE |
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