Prolonged recovery and respiratory depression after fentanyl infusion in a sheep undergoing mitral valve reconstruction
| Autor: | Olivier Levionnois, F S Eckstein, Yves Moens, Peter W Kronen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Narcotic Antagonists Sheep Diseases Intracardiac pressure law.invention Fentanyl law Internal medicine Mitral valve Cardiopulmonary bypass Animals Medicine Sheep General Veterinary Naloxone business.industry Extracorporeal circulation Mitral Valve Insufficiency Hypothermia medicine.anatomical_structure Isoflurane Anesthesia Anesthesia Recovery Period Cardiology Female Animal Science and Zoology medicine.symptom Respiratory Insufficiency business Propofol Anesthetics Intravenous medicine.drug |
| Zdroj: | Laboratory Animals. 39:428-434 |
| ISSN: | 1758-1117 0023-6772 |
| DOI: | 10.1258/002367705774286385 |
| Popis: | A sheep was anaesthetized for implantation of a novel device (MitroFast®) to replace the posterior leaflet of the mitral valve. Anaesthetic management included a balanced anaesthetic protocol and consisted of propofol or isoflurane combined with fentanyl infusion (0.15–0.4 μg/kg/min). Deliberate hypothermia during cardiopulmonary bypass was set at 34.5–35.5°C. Surgery proceeded uneventfully. Total time of aortic cross-clamping was 35 min and total time on extracorporeal circulation was 60 min. Visual inspection, intracardiac pressure testing and transesophageal echocardiography indicated proper functioning of the device. The anaesthetic period was uneventful, but recovery was prolonged with central nervous and respiratory depression and marked hypoxaemia. Administration of naloxone (1.5 μg/kg, repeated twice at 15–20 min intervals) reversed the central nervous and attenuated the respiratory depressions. An initially low rate of urine production normalized after rewarming and a single intravenous administration of furosemide. |
| Databáze: | OpenAIRE |
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