Tripartite relationship among P300, clinical features and brain structure in neuroleptic-naive schizophrenia

Autor:	Ken-Yo Hoshino, Eiichi Jodo, Satoshi Takeuchi, Shin-Ichi Niwa, Yukihiko Kayama, Yoshiaki Suzuki
Rok vydání:	2005
Předmět:	Adult Male medicine.medical_specialty Psychosis Electroencephalography Audiology Anxiety Neuroimaging Event-related potential medicine Humans Depression (differential diagnoses) Psychiatric Status Rating Scales Depressive Disorder medicine.diagnostic_test Positive and Negative Syndrome Scale General Neuroscience Brain General Medicine medicine.disease Event-Related Potentials P300 Psychiatry and Mental health Neurology Schizophrenia Evoked Potentials Auditory Female Schizophrenic Psychology Neurology (clinical) medicine.symptom Psychology Tomography X-Ray Computed Neuroscience Antipsychotic Agents
Zdroj:	Psychiatry and clinical neurosciences. 59(4)
ISSN:	1323-1316
Popis:	Auditory P300 abnormalities in schizophrenia patients have been repeatedly reported by many studies. However, reported relationships among P300 abnormalities, clinical features and other biological variables, such as abnormalities in structural brain imaging, are notably discrepant. This is partially due to the inclusion of patients who have had long-term administration of neuroleptics and those from whom this treatment has been withdrawn. The present study measures event-related potentials in 13 neuroleptic-naive schizophrenia patients using an auditory oddball paradigm to clarify the relationships among P300 amplitude, clinical features and brain structure. All patients underwent computed tomography to estimate the area of the right and left frontal cortical sulci and Sylvian fissures. Clinical symptoms were assessed using the Positive And Negative Syndrome Scale. The high correlation coefficients were obtained between P300 amplitude and the anxiety/depression factor score (r = -0.77), the positive factor score (r = -0.58) and between P300 amplitude and the area ratios of the fronto-temporal region (r = -0.66). These findings show that fronto-temporal region and P300 amplitude are closely related to the earliest stage of illness even in neuroleptic-naive patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40bb432bd6f0f471304a4a4b4a54553 https://pubmed.ncbi.nlm.nih.gov/16048446 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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