Protection against Shiga Toxins
| Autor: | Kirsten Sandvig, Simona Kavaliauskiene, Tore Skotland, Anne Berit Dyve Lingelem |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell type Shigella dysenteriae Protein Conformation Health Toxicology and Mutagenesis Antidotes Globotriaosylceramide lcsh:Medicine Apoptosis Review Shiga Toxins Toxicology medicine.disease_cause fluorodeoxyglucose chloroquine Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound symbols.namesake Bacterial Proteins inhibitors medicine Animals Humans Furin Dysentery Bacillary Shiga-Toxigenic Escherichia coli biology Toxin Trihexosylceramides Endoplasmic reticulum lcsh:R Shiga toxin Golgi apparatus Protein Transport Cytosol 030104 developmental biology chemistry Biochemistry Protein Biosynthesis Mn2+ Hemolytic-Uremic Syndrome Host-Pathogen Interactions hemolytic uremic syndrome biology.protein symbols Stx1 Stx2 |
| Zdroj: | Toxins, Vol 9, Iss 2, p 44 (2017) Toxins |
| ISSN: | 2072-6651 |
| Popis: | Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmic reticulum. The enzymatically active part of the A-moiety is then translocated to the cytosol, where it inhibits protein synthesis and in some cell types induces apoptosis. Protection of cells can be provided either by inhibiting binding of the toxin to cells or by interfering with any of the subsequent steps required for its toxic effect. In this article we provide a brief overview of the interaction of Shiga toxins with cells, describe some compounds and conditions found to protect cells against Shiga toxins, and discuss whether they might also provide protection in animals and humans. |
| Databáze: | OpenAIRE |
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