Synthesis of Benzopyran Linked Pyrrolo[2,1-c][1,4]benzodiazepines as DNA-Binding and Potential Anticancer Agents
| Autor: | Methuku Kashi Reddy, Ahmed Kamal, Gajjela Bharath Kumar, Vangala Santhosh Reddy, Rajender |
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| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
Biological Availability Antineoplastic Agents Chemistry Techniques Synthetic Nucleic Acid Denaturation Benzodiazepines Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Cell Line Tumor Drug Discovery Animals Humans Structure–activity relationship Inhibitory concentration 50 Cytotoxic T cell Benzopyrans Chemistry Temperature DNA DNA Restriction Enzymes Benzopyran Cell culture Drug Design Cattle Human cancer |
| Zdroj: | Medicinal Chemistry. 9:177-192 |
| ISSN: | 1573-4064 |
| DOI: | 10.2174/1573406411309020003 |
| Popis: | A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines. |
| Databáze: | OpenAIRE |
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