Spiral modiolar vein: its importance in viral load of the inner ear
| Autor: | Yukio Inuyama, Kazuo Ishikawa, Babür Küçük, Jeffrey P. Harris, Elizabeth M. Keithley, Satoshi Fukuda |
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| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty Guinea Pigs Cytomegalovirus Inflammation Biology Virus Veins Guinea pig 03 medical and health sciences 0302 clinical medicine otorhinolaryngologic diseases medicine Animals Inner ear 030223 otorhinolaryngology Vein Cochlea Venule Paramyxoviridae Infections General Medicine Anatomy biology.organism_classification Scala Tympani Sendai virus Parainfluenza Virus 1 Human Otitis Media medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Ear Inner Cytomegalovirus Infections Female sense organs medicine.symptom |
| Zdroj: | The Annals of otology, rhinologylaryngology. Supplement. 157 |
| ISSN: | 0096-8056 |
| Popis: | Guinea pig—specific cytomegalovirus and Sendai virus were inoculated into the cochleas of seronegative guinea pigs to study the route of entry of cells participating in inner ear inflammation. Inflammatory cells accumulated around the spiral modiolar vein and appeared to be streaming from this vein into the scala tympani via a collecting venule. Inactivated virus inoculated into the cochlea and normal control cochlea failed to show inflammatory cell infiltrates. The spiral modiolar vein appears to play an important role in the movement of cells from the systemic circulation into the inner ear as part of the host's normal defense against invading pathogens such as viruses. |
| Databáze: | OpenAIRE |
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