The Thioredoxin System as a Therapeutic Target in Human Health and Disease
| Autor: | Manuela Garcia Lopez, Javier Egea, KHADIJA EL HADRI, Sílvia Cardoso, Miguel Soares, Tatiana Syrovets, Dler Mahmood, Mustapha Rouis |
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| Přispěvatelé: | Vieillissement Cellulaire Intégré et Inflammation (VCII), Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Aging
Thioredoxin-Disulfide Reductase animal structures Physiology Clinical Biochemistry Inflammation Disease [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Pharmacology medicine.disease_cause Biochemistry Neuroprotection Immune system Thioredoxins Metabolic Diseases Neoplasms medicine Animals Humans Molecular Biology Exercise General Environmental Science Immunity Neurodegenerative Diseases Cell Biology Oxidative Stress Cardiovascular Diseases Cancer research General Earth and Planetary Sciences Thioredoxin medicine.symptom Oxidation-Reduction Function (biology) TXNIP Oxidative stress |
| Zdroj: | Antioxidants and Redox Signaling Antioxidants and Redox Signaling, Mary Ann Liebert, 2013, 19 (11), pp.1266-1303. ⟨10.1089/ars.2012.4757⟩ Antioxidants and Redox Signaling, 2013, 19 (11), pp.1266-1303. ⟨10.1089/ars.2012.4757⟩ |
| ISSN: | 1523-0864 |
| DOI: | 10.1089/ars.2012.4757⟩ |
| Popis: | International audience; The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This system is essential for maintaining the balance of the cellular redox status, and it is involved in the regulation of redox signaling. It is also pivotal for growth promotion, neuroprotection, inflammatory modulation, antiapoptosis, immune function, and atherosclerosis. As an ubiquitous and multifunctional protein, Trx is expressed in all forms of life, executing its function through its antioxidative, protein-reducing, and signal-transducing activities. In this review, the biological properties of the Trx system are highlighted, and its implications in several human diseases are discussed, including cardiovascular diseases, heart failure, stroke, inflammation, metabolic syndrome, neurodegenerative diseases, arthritis, and cancer. The last chapter addresses the emerging therapeutic approaches targeting the Trx system in human diseases. Antioxid. Redox Signal. 19, 1266-1303. |
| Databáze: | OpenAIRE |
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