Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat
| Autor: | Sylvie Bodard, Denis Guilloteau, Sylvie Chalon, Laurent Galineau, Catherine Belzung, Ercem Kodas |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Microdialysis Time Factors Nortropanes Dopamine Ecstasy Tyramine Hippocampus Striatum Biology Serotonergic Sex Factors Neurochemical Developmental Neuroscience Pregnancy Internal medicine Fenfluramine medicine Animals Rats Wistar 3 4-Methylenedioxyamphetamine Brain Chemistry Analysis of Variance Adrenergic Uptake Inhibitors Dopaminergic Age Factors Brain Membrane Transport Proteins Homovanillic Acid MDMA Hydroxyindoleacetic Acid Embryo Mammalian Rats Endocrinology Animals Newborn Prenatal Exposure Delayed Effects Anesthesia Hallucinogens 3 4-Dihydroxyphenylacetic Acid Autoradiography Female Selective Serotonin Reuptake Inhibitors Developmental Biology medicine.drug |
| Zdroj: | ResearcherID |
| ISSN: | 0165-3806 |
| DOI: | 10.1016/j.devbrainres.2004.10.012 |
| Popis: | We investigated several aspects of the dopaminergic and serotonergic functions throughout brain development in rats prenatally exposed to MDMA (“ecstasy”). Pregnant rats were treated with MDMA (10 mg/kg s.c.) or saline from the 13th to the 20th day of gestation and studies were conducted on the progeny from both groups: (i) quantification of whole brain contents of DA, 5-HT and metabolites from the 14th day of embryonic life (E14) to weaning (21st day of postnatal life, P21); (ii) quantification of DA and 5-HT membrane transporters by autoradiography from E18 to adult age (P70); (iii) measurement of pharmacologically induced release of DA and 5-HT using microdialysis on adult (P70) freely moving rats; (iv) measurement of sucrose preference in adults (P70). Prenatally MDMA-exposed rats showed (i) a two-fold decrease of whole brain levels of 5-HT and 5-HIAA at P0; (ii) no effect on the DAT and SERT density; (iii) a strongly reduced pharmacologically induced release of DA and 5-HT at P70 in the striatum and hippocampus; and (iv) a significant 20% decrease in sucrose preference at P70. This study suggests that a prenatal exposure to MDMA induces transient and long-term neurochemical and behavioural modifications in dopaminergic and serotonergic functions. |
| Databáze: | OpenAIRE |
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