A New Class of Chiral Pyrrolidine−Pyridine Conjugate Base Catalysts for Use in Asymmetric Michael Addition Reactions
| Autor: | Yusuke Sekiguchi, Shingo Fujioka, Hiyoshizo Kotsuki, Takaaki Ishii |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
inorganic chemicals Base (chemistry) organic chemicals education Cyclohexanone Homogeneous catalysis General Medicine General Chemistry Combinatorial chemistry Biochemistry humanities Catalysis Pyrrolidine Bifunctional catalyst chemistry.chemical_compound Colloid and Surface Chemistry chemistry Pyridine Michael reaction Organic chemistry Conjugate |
| Zdroj: | Journal of the American Chemical Society. 126:9558-9559 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja046871g |
| Popis: | Direct catalytic asymmetric Michael addition reactions of ketones to nitroolefins using newly developed chiral pyrrolidine-pyridine conjugate bases as catalysts are described. The desired 1,4-adducts are obtained in excellent yields with high enantio- and diastereoselectivities. |
| Databáze: | OpenAIRE |
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