A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction

Autor: Svenja Hinderer, Lenka Kovarova, Nathalie Braun, Peter Dockery, Bruce P. Murphy, M. Hamman de Vaal, Garry P. Duffy, Vladimir Velebny, Gabriella Bellavia, Hugh O'Neill, Martin Pravda, Michael G. Monaghan, Helena M. Kelly, Katja Schenke-Layland, Robert Greensmith, Dorothee Daro, Stefania Straino, Stephen Wildhirt, Ruth E. Levey, Björn Hofmann, Eimear B. Dolan, David S. Monahan
Přispěvatelé: Seventh Framework Programme, Irish Research Council, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway
Rok vydání: 2018
Předmět:
medicine.medical_specialty
Materials science
Swine
Cell- and Tissue-Based Therapy
Myocardial Infarction
Bioengineering
Stem cell delivery
Biocompatible Materials
02 engineering and technology
010402 general chemistry
Mesenchymal Stem Cell Transplantation
01 natural sciences
Biomaterials
Cell Movement
Internal medicine
Absorbable Implants
medicine
Epicardial carrier device
Hyaluronic acid hydrogel
Animals
Humans
Myocardial infarction
Hyaluronic Acid
Ejection fraction
Viscosity
Regeneration (biology)
Hydrogels
Mesenchymal Stem Cells
Equipment Design
021001 nanoscience & nanotechnology
medicine.disease
Extravascular device
0104 chemical sciences
medicine.anatomical_structure
Adipose Tissue
Mechanics of Materials
Ventricle
Heart failure
Self-healing hydrogels
Cardiology
Female
Stem cell
0210 nano-technology
Ventricular stabilization
Pericardium
Blood vessel
Zdroj: Materials scienceengineering. C, Materials for biological applications. 103
ISSN: 1873-0191
Popis: The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the weakened myocardium and regenerative approaches (specifically stem cell technologies) have evolved which aim to prevent CHF. However, their final performance remains limited motivating the need for an advanced strategy with enhanced efficacy and reduced deleterious effects. An epicardial carrier device enabling a targeted application of a biomaterial-based therapy to the infarcted ventricle wall could potentially overcome the therapy and application related issues. Such a device could play a synergistic role in heart regeneration, including the provision of mechanical support to the remodeling heart wall, as well as providing a suitable environment for in situ stem cell delivery potentially promoting heart regeneration. In this study, we have developed a novel, single-stage concept to support the weakened myocardial region post-MI by applying an elastic, biodegradable patch (SPREADS) via a minimal-invasive, closed chest intervention to the epicardial heart surface. We show a significant increase in %LVEF 14 days post-treatment when GS (clinical gold standard treatment) was compared to GS + SPREADS + Gel with and without cells (p ≤ 0.001). Furthermore, we did not find a significant difference in infarct quality or blood vessel density between any of the groups which suggests that neither infarct quality nor vascularization is the mechanism of action of SPREADS. The SPREADS device could potentially be used to deliver a range of new or previously developed biomaterial hydrogels, a remarkable potential to overcome the translational hurdles associated with hydrogel delivery to the heart. AMCARE project funded by European Union's ‘Seventh Framework’ Programme for research, technological development and demonstration under Grant Agreement n° NMP3-SME-2013-604531. David Monahan is funded by the Irish Research Council Government of Ireland Postgraduate Scholarship (GOIPG/2017/927) and the College of Medicine, Nursing and Health Sciences at the National University of Ireland Galway. Scott Robinson for statistical analysis. The authors acknowledge the facilities, scientific, and technical assistance of the Centre for Microscopy & Imaging at the National University of Ireland Galway. peer-reviewed 2021-05-15
Databáze: OpenAIRE
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