Preserved fractal character of structural brain networks is associated with covert consciousness after severe brain injury
| Autor: | David K. Menon, Michael M. Craig, Andrea I. Luppi, Judith Allanson, John D. Pickard, Guy B. Williams, Alexander R. D. Peattie, Emmanuel Stamatakis, Paola Finoia, Peter Coppola |
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| Přispěvatelé: | Luppi, Andrea [0000-0002-3461-6431], Williams, Guy [0000-0001-5223-6654], Pickard, John [0000-0002-5762-6667], Stamatakis, Emmanuel [0000-0001-6955-9601], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Consciousness
Cognitive Neuroscience media_common.quotation_subject Computer applications to medicine. Medical informatics R858-859.7 Disorders of consciousness 050105 experimental psychology Diffusion MRI 03 medical and health sciences 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Brain injury Cognitive-motor dissociation RC346-429 media_common business.industry 05 social sciences Brain Minimally conscious state Cognition Human brain medicine.disease Brain network Fractals medicine.anatomical_structure Neurology Brain Injuries Consciousness Disorders Wakefulness Neurology (clinical) Neurology. Diseases of the nervous system business Fractal Neuroscience 030217 neurology & neurosurgery Tractography |
| Zdroj: | NeuroImage: Clinical, Vol 30, Iss, Pp 102682-(2021) |
| ISSN: | 2213-1582 |
| Popis: | Self-similarity is ubiquitous throughout natural phenomena, including the human brain. Recent evidence indicates that fractal dimension of functional brain networks, a measure of self-similarity, is diminished in patients diagnosed with disorders of consciousness arising from severe brain injury. Here, we set out to investigate whether loss of self-similarity is observed in the structural connectome of patients with disorders of consciousness. Using diffusion MRI tractography from N = 11 patients in a minimally conscious state (MCS), N = 10 patients diagnosed with unresponsive wakefulness syndrome (UWS), and N = 20 healthy controls, we show that fractal dimension of structural brain networks is diminished in DOC patients. Remarkably, we also show that fractal dimension of structural brain networks is preserved in patients who exhibit evidence of covert consciousness by performing mental imagery tasks during functional MRI scanning. These results demonstrate that differences in fractal dimension of structural brain networks are quantitatively associated with chronic loss of consciousness induced by severe brain injury, highlighting the close connection between structural organisation of the human brain and its ability to support cognitive function. |
| Databáze: | OpenAIRE |
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