Plasma phytoestrogens concentration and risk of colorectal cancer in two different Asian populations
| Autor: | Le Tran Ngoan, Keun-Young Yoo, Young Khi Lim, Shinkan Tokudome, Chul Hwan Kang, Yohwan Yeo, Chihaya Koriyama, Hai Rim Shin, Kwang Pil Ko, Cheong Sik Kim, Ji Hye Yoon, Daehee Kang, Soung Hoon Chang, Sue K. Park |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Population Genistein Phytoestrogens Critical Care and Intensive Care Medicine Lignans 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enterolactone 4-Butyrolactone Asian People Risk Factors Internal medicine Republic of Korea medicine Humans education Aged education.field_of_study Nutrition and Dietetics business.industry Daidzein food and beverages Cancer Odds ratio Middle Aged medicine.disease Isoflavones 030104 developmental biology Endocrinology chemistry Vietnam 030220 oncology & carcinogenesis Case-Control Studies Population study Female business Colorectal Neoplasms |
| Zdroj: | Clinical nutrition (Edinburgh, Scotland). 37(5) |
| ISSN: | 1532-1983 |
| Popis: | Summary Background & aims To evaluate the relationship between phytoestrogen and colon cancer risk, we quantified plasma isoflavones (Genistein and Daidzein) and lignan (enterolactone) in a Korean nested case-control study and conducted replication study in a Vietnamese case-control study. Methods Study populations of 101 cases and 391 controls were selected from the Korean Multicenter Cancer Cohort which was constructed from 1993 to 2004. For replication study, Vietnamese hospital-based case-control subjects of 222 cases and 206 controls were selected from 2003 to 2007. The concentrations of plasma genistein, daidzein, and enterolactone were quantified by liquid chromatography-mass spectrometry. Logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs), and meta-analysis was conducted to estimate combined ORs (CORs) and 95% Cis of Korean and Vietnamese population in 2014. Results Genistein showed a continual decrease in colorectal cancer risk according to level up of the concentration categories in Korean and Vietnamese population ( P for trend = 0.032, and 0.001, respectively) and a significantly decreased risk was found at the highest concentration of genistein and daidzein (for the highest category compared to the lowest: COR (95% CI) = 0.46 (0.30–0.69), and COR (95% CI) = 0.54 (0.36–0.82)). When the study population was stratified, the beneficial relationship of genistein with colorectal cancer was observed regardless of sex and anatomical subtype. However, enterolacton level was not associated with colorectal cancer risk. Conclusions High plasma levels of isoflavones had relationship with a decreased risk of colorectal cancer, regardless of different ethnic background. |
| Databáze: | OpenAIRE |
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