Comparative studies of somatostatin-14 and some of its fragments on passive avoidance behavior, open field activity and on barrel rotation phenomenon in rats
| Autor: | Botond Penke, László Vécsei, Imre Pavo, Jozsef Zsigo, Erik Widerlöv |
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| Rok vydání: | 1989 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Rotation Physiology Molecular Sequence Data Barrel (horology) Neuropeptide Motor Activity Peptide hormone Biochemistry Open field Cellular and Molecular Neuroscience Endocrinology Internal medicine Avoidance Learning medicine Animals Amino Acid Sequence Latency (engineering) Injections Intraventricular Behavior Animal Chemistry Rats Inbred Strains Peptide Fragments Rats Somatostatin Behavioral test Passive avoidance hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 10:1153-1157 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/0196-9781(89)90007-7 |
| Popis: | Behavioral effects of somatostatin-14, and some of its fragments [somatostatin(3–8), somatostatin(9–14), somatostatin(7–10)] after intracerebroventricular (ICV) administration have been investigated in male rats. In a passive avoidance learning test, somatostatin-14 (0.6 nM) given immediately after the learning session increased the avoidance latency at 24 hr after the injection, when compared to a somatostatin(3–8) (0.6 nM)-treated group. However, compared to a saline-treated group, the peptides did not significantly influence the avoidance latency. Somatostatin-14 administered in higher dose (6.0 nM) decreased the avoidance latency compared to the saline-treated group, while its fragments did not influence it. In an open field behavioral test, immediately after the 24-hr passive avoidance test, 6 nM of somatostatin-14 decreased the rearing activity, while the fragments did not influence this behavior. Somatostatin-14 produced barrel rotation in a dose-related manner, but after the injection of a high dose of the peptide (12 nM) all of the animals died in cardiorespiratory failure (apnea, pulmonary oedema). The fragments did not produce barrel rotation. |
| Databáze: | OpenAIRE |
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