Upslope treadmill exercise enhances motor axon regeneration but not functional recovery following peripheral nerve injury
| Autor: | Krista Osborne, Kelly LeFevere Werts, Jill Cannoy, Allen Jarratt, Sam Crowley, Sohee Park, Arthur W. English |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Electromyography Walking 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Peripheral Nerve Injuries Reflex Medicine Animals Axon Treadmill Muscle Skeletal Soleus muscle Motor Neurons medicine.diagnostic_test business.industry General Neuroscience Recovery of Function Sciatic nerve injury medicine.disease Sciatic Nerve Axons Biomechanical Phenomena Exercise Therapy Hindlimb Nerve Regeneration Disease Models Animal 030104 developmental biology medicine.anatomical_structure Rats Inbred Lew Anesthesia Peripheral nerve injury Call for Papers Female Sciatic nerve business human activities 030217 neurology & neurosurgery Reinnervation |
| Zdroj: | Journal of neurophysiology. 116(3) |
| ISSN: | 1522-1598 |
| Popis: | Following peripheral nerve injury, moderate daily exercise conducted on a level treadmill results in enhanced axon regeneration and modest improvements in functional recovery. If the exercise is conducted on an upwardly inclined treadmill, even more motor axons regenerate successfully and reinnervate muscle targets. Whether this increased motor axon regeneration also results in greater improvement in functional recovery from sciatic nerve injury was studied. Axon regeneration and muscle reinnervation were studied in Lewis rats over an 11 wk postinjury period using stimulus evoked electromyographic (EMG) responses in the soleus muscle of awake animals. Motor axon regeneration and muscle reinnervation were enhanced in slope-trained rats. Direct muscle (M) responses reappeared faster in slope-trained animals than in other groups and ultimately were larger than untreated animals. The amplitude of monosynaptic H reflexes recorded from slope-trained rats remained significantly smaller than all other groups of animals for the duration of the study. The restoration of the amplitude and pattern of locomotor EMG activity in soleus and tibialis anterior and of hindblimb kinematics was studied during treadmill walking on different slopes. Slope-trained rats did not recover the ability to modulate the intensity of locomotor EMG activity with slope. Patterned EMG activity in flexor and extensor muscles was not noted in slope-trained rats. Neither hindblimb length nor limb orientation during level, upslope, or downslope walking was restored in slope-trained rats. Slope training enhanced motor axon regeneration but did not improve functional recovery following sciatic nerve transection and repair. |
| Databáze: | OpenAIRE |
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