Clinical features of patients with -lactamase producing Haemophilus influenzae isolated from sputum
| Autor: | Hilary Humphreys, S. R. Johnson, R. C. F. Thompson, J. T. Macfarlane |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Lung Diseases Male Microbiology (medical) Haemophilus Infections medicine.disease_cause beta-Lactamases Microbiology Haemophilus influenzae Amp resistance Ampicillin Lower respiratory tract infection medicine Humans Pharmacology (medical) Beta (finance) Respiratory Tract Infections Aged Retrospective Studies Antibacterial agent Aged 80 and over Pharmacology business.industry Smoking Sputum Middle Aged Amoxicillin medicine.disease Anti-Bacterial Agents Infectious Diseases Chronic Disease Female medicine.symptom business Ampicillin Resistance medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 38:881-884 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/38.5.881 |
| Popis: | Ampicillin resistance amongst isolates of Haemophilus influenzae is of increasing concern but its clinical impact is unclear. We performed a retrospective study of 34 hospital patients with lower respiratory tract infection (LRTI) caused by beta-lactamase positive (beta+) H. influenzae and compared these with 34 control patients with LRTI caused by beta-lactamase negative (beta-) strains. Chronic obstructive pulmonary disease was the most common underlying condition in both groups (beta+ 23/24, beta- 25/34). A recent course of antibiotics, especially ampicillin/amoxycillin, was significantly (P < 0.05) more common in the beta+ group (beta+ 17/34, beta- 3/34). Other pathogens were isolated more frequently in the beta+ group (beta+ 10/34, beta- 4/34). There was no difference in outcome between the two groups. |
| Databáze: | OpenAIRE |
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