The effect of isolated soy protein adjunctive with flaxseed oil on markers of inflammation, oxidative stress, acute phase proteins, and wound healing of burn patients; a randomized clinical trial

Autor: Peyman Jafari, Seyed Mohammad Mazloomi, Siavash Babajafari Esfandabad, Mehdi Ayaz, Ali Noorafshan, Masoumeh Akhlaghi
Rok vydání: 2018
Předmět:
Male
Critical Care and Intensive Care Medicine
medicine.disease_cause
Gastroenterology
law.invention
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
law
Malondialdehyde
Medicine
030212 general & internal medicine
biology
Acute-phase protein
General Medicine
Middle Aged
C-Reactive Protein
Soybean Proteins
Emergency Medicine
Female
Burns
Adult
medicine.medical_specialty
Linseed Oil
Adolescent
Young Adult
03 medical and health sciences
Double-Blind Method
Internal medicine
Humans
Inflammation
Wound Healing
Intention-to-treat analysis
Superoxide Dismutase
business.industry
Albumin
030208 emergency & critical care medicine
Surgery
Ferritin
Oxidative Stress
chemistry
Dietary Supplements
biology.protein
business
Wound healing
Biomarkers
Oxidative stress
Acute-Phase Proteins
Zdroj: Burns. 44:140-149
ISSN: 0305-4179
DOI: 10.1016/j.burns.2017.05.014
Popis: The objective was to determine the effect of isolated soy protein (ISP) and flaxseed oil (FO) on inflammatory and oxidative stress indices, acute phase proteins, and wound healing of burn patients.One hundred eighty-eight patients were assessed for eligibility in this randomized controlled trial. Of these, seventy-three eligible patients (total burn surface area 20-50%) were randomly assigned to 3 isocaloric groups, labeled as control (wheat flour+corn oil (CO)), ISP+FO, and ISP+CO, to receive these nutrients for 3 weeks. We used intention to treat analysis to overcome bias. Because of the large perturbation in water compartments, patients received nutrients from 4th to 25th day of admission. Serum high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), superoxide dismutase (SOD), ferritin, albumin, and transferrin were measured. The wound area was evaluated by stereological test.During the 3-week intervention, hs-CRP (-19.4±5.6, -11.7±4.7μg/ml) and ferritin (-83.8±20.5, -80.1±19.6ng/ml) levels changes significantly reduced compared to the control group (P0.05). MDA level (-0.05±0.21μmol/l) significantly decreased in group A (P0/05) but was not significant in groups B and control (P0.05). Albumin level (0.59±0.14, 0.30±0.12g/dl) significantly increased in group A compared to the control group (P0.05), but no significant relationship was found between other groups (P0.05). Transferrin level (4.9±3.6, 2.9±5.1g/dl) significantly increased in ISP groups compared to the control (P0.05). SOD improved in all groups with no significant difference between them (P0.05). The stereology examination showed significant improvement in wound healing in the ISP groups on days 22 and 25 compared to the control group.Nutritional supplements with ISP may attenuate post-burn oxidative stress and inflammation, leading to improved wound healing in burn patients. Flaxseed oil may not exert a beneficial effect over the ISP.
Databáze: OpenAIRE
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