Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths
| Autor: | Sylvie Berrard, Corinna Schnoeller, Menno J. Oudhoff, Kleoniki Gounaris, Rachel Vaux, Delphine Sedda, Naveen Parmar, William G. C. Horsnell, Valérie F. J. Quesniaux, Claire Mackowiak, Jamie Pillaye, Luke B. Roberts, David R. Withers, Matthew Darby, Murray E. Selkirk, Rita Berkachy, Bernhard Ryffel |
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| Přispěvatelé: | Imperial College London |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Immunology Helminthiasis Gene Expression Host-Parasite Interactions Immunophenotyping 03 medical and health sciences 0302 clinical medicine In vivo Helminths medicine Animals Nippostrongylus brasiliensis Immunity Mucosal ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences biology Innate lymphoid cell Nuclear Receptor Subfamily 1 Group F Member 1 General Medicine biology.organism_classification medicine.disease Phenotype Immunohistochemistry In vitro Acetylcholine Immunity Innate Lymphocyte Subsets 3. Good health Nematode infection Organ Specificity Cholinergic Cytokines Biomarkers 030215 immunology medicine.drug |
| Zdroj: | Science Immunology Science Immunology, American Association for the Advancement of Science, 2021, 6 (57), ⟨10.1126/sciimmunol.abd0359⟩ |
| ISSN: | 2470-9468 |
| DOI: | 10.1126/sciimmunol.abd0359⟩ |
| Popis: | Innate lymphoid cells (ILCs) are critical mediators of immunological and physiological responses at mucosal barrier sites. Whereas neurotransmitters can stimulate ILCs, the synthesis of small-molecule neurotransmitters by these cells has only recently been appreciated. Group 2 ILCs (ILC2s) are shown here to synthesize and release acetylcholine (ACh) during parasitic nematode infection. The cholinergic phenotype of pulmonary ILC2s was associated with their activation state, could be induced by in vivo exposure to extracts of Alternaria alternata or the alarmin cytokines interleukin-33 (IL-33) and IL-25, and was augmented by IL-2 in vitro. Genetic disruption of ACh synthesis by murine ILC2s resulted in increased parasite burdens, lower numbers of ILC2s, and reduced lung and gut barrier responses to Nippostrongylus brasiliensis infection. These data demonstrate a functional role for ILC2-derived ACh in the expansion of ILC2s for maximal induction of type 2 immunity. |
| Databáze: | OpenAIRE |
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