Effects of two-dose ceftiofur treatment for metritis on the temporal dynamics of antimicrobial resistance among fecal Escherichia coli in Holstein-Friesian dairy cows

Autor: E.R. Jordan, Juan M. Piñeiro, Harvey Morgan Scott, Jose A. Garcia, Keri N. Norman, Gerrit R. Hagevoort, Sara D. Lawhon, Ethan A. Taylor
Rok vydání: 2019
Předmět:
0301 basic medicine
Physiology
Animal Slaughter
Ice calving
Endocrinology
Mathematical and Statistical Techniques
Antibiotics
Reproductive Physiology
Medicine and Health Sciences
Metritis
Animal Management
education.field_of_study
Multidisciplinary
Antimicrobials
Enteric Bacteria
Statistics
Drugs
food and beverages
Agriculture
Anti-Bacterial Agents
Physical Sciences
Regression Analysis
Medicine
Female
Sample collection
Endometritis
Ceftiofur
Research Article
Veterinary Medicine
Extraintestinal Pathogenic Escherichia coli
Science
030106 microbiology
Population
Cattle Diseases
Linear Regression Analysis
Biology
Research and Analysis Methods
Microbiology
Drug Administration Schedule
Milking
03 medical and health sciences
Animal science
Microbial Control
Drug Resistance
Bacterial
medicine
Lactation
Animals
Statistical Methods
education
Feces
Pharmacology
Arithmetic
Endocrine Physiology
Bacteria
Organisms
Biology and Life Sciences
medicine.disease
Cephalosporins
030104 developmental biology
Herd
Veterinary Science
Livestock Care
Cattle
Antimicrobial Resistance
Mathematics
Zdroj: PLoS ONE, Vol 14, Iss 7, p e0220068 (2019)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0220068
Popis: A pair-matched longitudinal study conducted on three dairy farms in the U.S. High-Plains explored the temporal effects of two-dose ceftiofur crystalline-free acid (CCFA) treatment for metritis on third-generation cephalosporin (3GC) resistance among enteric E. coli in Holstein-Friesian cows. The current 13-day slaughter withholding period does not account for rising populations of third-generation cephalosporin (3GC) resistant bacteria in feces of animals following CCFA treatment. A total of 124 matched-pairs of cows were enrolled in the study. Cows diagnosed with postpartum metritis received the product twice at the labeled dose of 6.6 mg/kg subcutaneously at the base of alternating ears. Untreated cows–absent clinical metritis–were matched on lactation number and calving date. Feces were collected per rectum on days 0 (baseline), 6, 16, 28, and 56. Environmental samples, from watering troughs as well as surface manure from fresh-cow, hospital, maternity, and milking pens, and from the compost pile were collected prior to the animal sample collection period. Historical data on metritis rates and CCFA use were compiled from herd records. On day 0, cows exhibited an overall mean difference of over 4 log10 colony forming units (CFU) comparing 3GC resistant E. coli to the general E. coli population. At the first eligible slaughter date, the difference declined to 3.31 log10 CFU among cows in the CCFA group (P
Databáze: OpenAIRE
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