The effect of maternal smoking and ethanol on fatty acid transport by the human placenta
Autor: | David Abramovich, Paul Haggarty, Kenneth Robert Page |
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Rok vydání: | 2002 |
Předmět: |
medicine.medical_specialty
Docosahexaenoic Acids Placenta Medicine (miscellaneous) Alcohol Biology chemistry.chemical_compound Pregnancy Internal medicine medicine Humans Maternal-Fetal Exchange chemistry.chemical_classification Arachidonic Acid Nutrition and Dietetics Ethanol alpha-Linolenic acid Smoking alpha-Linolenic Acid Fatty acid Metabolism Endocrinology medicine.anatomical_structure Biochemistry chemistry Docosahexaenoic acid Fatty Acids Unsaturated Female Arachidonic acid Polyunsaturated fatty acid |
Zdroj: | British Journal of Nutrition. 87:247-252 |
ISSN: | 1475-2662 0007-1145 |
Popis: | The role of the placenta in controlling the supply of fatty acids to the fetus was investigated in term placentas from non-smokers (n5), smokers (>ten cigarettes/d;n5) and after addition of ethanol at 2 mg/ml (n4). The maternal side was of the placenta was perfusedex vivofor 90 min with a physiological mixture of fatty acids and fatty acid:human albumin ratio. There was no effect of smoking on the transfer of linoleic (LA, 18 : 2n-6), α-linolenic (αLN, 18 : 3n-3), arachidonic (AA, 20 : 4n-6) or docosahexaenoic acid (DHA, 22 : 6n-3), expressed per perfused area (calculated from H218O exchange). However, the presence of ethanol in the perfusate at a concentration of 2 mg/ml significantly reduced (Pn-3 polyunsaturated fatty acids, αLN and DHA. This specific effect of ethanol on αLN and DHA also resulted in an altered selectivity for transfer of individual fatty acids. In the non-smoking control group the placenta selectively transferred polyunsaturated fatty acids to the fetus in the order DHA>AA>αLN>LA. The order of selectivity was unaltered in placentas from smokers, but the addition of ethanol to the perfusion medium altered the order of selectivity to AA>αLN>LA>DHA. The presence of ethanol in the perfusate was also associated with a significant reduction (P218O. These results suggest that the presence of ethanol at a concentration of 2 mg/ml may reduce the availability of polyunsaturated fatty acids to the developing fetus. |
Databáze: | OpenAIRE |
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