Do Polymicrobial Intra-Abdominal Infections Have Worse Outcomes than Monomicrobial Intra-Abdominal Infections?
| Autor: | Zachary C. Dietch, Sara A. Hennessy, Brandy L. Edwards, Puja M. Shah, Christopher A. Guidry, Reza Askari, Charles H. Cook, Kimberly Popovsky, Robert G. Sawyer, Stephen W. Davies, Raul Coimbra, Therese M. Duane, Patrick J. O'Neill |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Polymicrobial infection Adolescent Surgical Infection Society Articles medicine.drug_class 030106 microbiology Antibiotics law.invention Young Adult 03 medical and health sciences Microorganism interaction symbols.namesake Randomized controlled trial Recurrence law Internal medicine Antibiotic therapy medicine Humans Surgical Wound Infection Prospective Studies Fisher's exact test Aged Peritoneal Infection Aged 80 and over Coinfection business.industry Abdominal Infection Bacterial Infections Middle Aged Survival Analysis Anti-Bacterial Agents Surgery Treatment Outcome 030104 developmental biology Infectious Diseases symbols Intraabdominal Infections Female business |
| Zdroj: | Surgical Infections. 17:27-31 |
| ISSN: | 1557-8674 1096-2964 |
| DOI: | 10.1089/sur.2015.127 |
| Popis: | Numerous studies have demonstrated microorganism interaction through signaling molecules, some of which are recognized by other bacterial species. This interspecies synergy can prove detrimental to the human host in polymicrobial infections. We hypothesized that polymicrobial intra-abdominal infections (IAI) have worse outcomes than monomicrobial infections.Data from the Study to Optimize Peritoneal Infection Therapy (STOP-IT), a prospective, multicenter, randomized controlled trial, were reviewed for all occurrences of IAI having culture results available. Patients in STOP-IT had been randomized to receive four days of antibiotics vs. antibiotics until two days after clinical symptom resolution. Patients with polymicrobial and monomicrobial infections were compared by univariable analysis using the Wilcoxon rank sum, χ(2), and Fisher exact tests.Culture results were available for 336 of 518 patients (65%). The durations of antibiotic therapy in polymicrobial (n = 225) and monomicrobial IAI (n = 111) were equal (p = 0.78). Univariable analysis demonstrated similar demographics in the two populations. The 37 patients (11%) with inflammatory bowel disease were more likely to have polymicrobial IAI (p = 0.05). Polymicrobial infections were not associated with a higher risk of surgical site infection, recurrent IAI, or death.Contrary to our hypothesis, polymicrobial IAI do not have worse outcomes than monomicrobial infections. These results suggest polymicrobial IAI can be treated the same as monomicrobial IAI. |
| Databáze: | OpenAIRE |
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