Depressive Symptoms and the Relationship of Inflammation to Physical Signs and Symptoms in Heart Failure Patients
| Autor: | Terry A. Lennie, Rebecca L. Dekker, Sandra B. Dunbar, Debra K. Moser, Seongkum Heo, Susan J. Pressler |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_specialty Comorbidity Critical Care Nursing Affect (psychology) Article Body Mass Index Social support Quality of life Internal medicine Edema Humans Medicine Prospective Studies Prospective cohort study Fatigue Depression (differential diagnoses) Aged Heart Failure Inflammation Psychiatric Status Rating Scales Depression business.industry fungi Social Support food and beverages General Medicine Middle Aged medicine.disease Dyspnea Receptors Tumor Necrosis Factor Type I Heart failure Physical therapy Female business Body mass index |
| Zdroj: | American Journal of Critical Care. 23:404-413 |
| ISSN: | 1937-710X 1062-3264 |
| DOI: | 10.4037/ajcc2014614 |
| Popis: | Depressive symptoms in patients with heart failure can affect the relationship between physical signs and symptoms and inflammation.To examine the relationship between soluble tumor necrosis factor receptor I and physical signs and symptoms and the effects of depressive symptoms on this relationship in patients with heart failure.Data on physical signs and symptoms (Symptom Status Questionnaire-Heart Failure), depressive symptoms (Beck Depression Inventory-II), and levels of the receptor (blood samples) were collected from 145 patients with heart failure. Data on the receptor were square root transformed to achieve normality. Patients were divided into 2 groups according to their scores for depressive symptoms (nondepressed14 and depressed ≥14). Hierarchical multiple regression was used to analyze the data.In the total sample, with controls for covariates, higher levels of the receptor were significantly related to more severe physical signs and symptoms (F = 7.915; P.001). In subgroup analyses, with controls for covariates, levels of the receptor were significantly related to physical signs and symptoms only in the patients without depression (F = 3.174; P = .005).Both depressive symptoms and inflammation should be considered along with physical signs and symptoms in patients with heart failure. Further studies are needed to determine the effects of improvement in inflammation on improvement in physical signs and symptoms, with consideration given to the effects of depressive symptoms. |
| Databáze: | OpenAIRE |
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