Dalbergieae lectins: A review of lectins from species of a primitive Papilionoideae (leguminous) tribe
| Autor: | Vinicius Jose Da Silva Osterne, Vanir Reis Pinto-Junior, Mayara Torquato Lima Silva, Benildo Sousa Cavada, Kyria S. Nascimento, Messias Vital Oliveira, Claudia Figueiredo Lossio |
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| Rok vydání: | 2020 |
| Předmět: |
Protein Folding
Subfamily Carbohydrates 02 engineering and technology Plant Lectins Dalbergieae Leguminoseae Tribe (biology) Biochemistry 03 medical and health sciences Structural Biology Molecular Biology 030304 developmental biology 0303 health sciences Binding Sites biology food and beverages Lectin Fabaceae General Medicine 021001 nanoscience & nanotechnology biology.organism_classification Arachis hypogaea Structural Homology Protein biology.protein 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 144:509-526 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2019.12.117 |
| Popis: | Lectins are (glyco)proteins capable of reversibly binding to specific carbohydrates, thus having various functions and applications. Plant lectins are the best studied, and the Leguminoseae family is highlighted in a number of published works, especially species of the Papilionoideae subfamily. Dalbergieae is one of the tribes in this subfamily comprising 49 genera and over 1300 species. From this tribe, about 26 lectins were studied, among which we can highlight the Arachis hypogaea lectin, widely used in cancer studies. Dalbergieae lectins demonstrate various carbohydrate specificities and biological activities including anti-inflammatory, vasorelaxant, nociceptive, antibacterial, antiviral among others. Structurally, these lectins are quite similar in their three-dimensional folding but present significant differences in oligomerization patterns and in the conservation of carbohydrate-recognition domain. Despite the existence of structural data from some lectins, only sparse literature has reported on this tribe's diversity, not to mention the range of biological effects, determined through specific assays. Therefore, this work will review the most important studies on Dalbergieae lectins and their potential biomedical applications. |
| Databáze: | OpenAIRE |
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