Effect of vitamin E in nonalcoholic fatty liver disease with metabolic syndrome: A propensity score-matched cohort study
| Autor: | Sook-Hyang Jeong, Jin Wook Kim, Dong Ho Lee, Cheol Min Shin, Jong Ho Lee, Nayoung Kim, Kyeong Sam Ok, Jaihwan Kim, Jin-Hyeok Hwang, Gi Hyun Kim, Young Su Park, Eun Sun Jang, Jung Wha Chung |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Propensity score medicine.medical_treatment Gastroenterology Cohort Studies Non-alcoholic Fatty Liver Disease Internal medicine Republic of Korea Nonalcoholic fatty liver disease medicine Humans Vitamin E Aspartate Aminotransferases lcsh:RC799-869 Molecular Biology Aged Retrospective Studies Hepatology biology business.industry Body Weight Alanine Transaminase Retrospective cohort study Middle Aged medicine.disease Metabolic syndrome Lipoproteins LDL Endocrinology Liver Alanine transaminase Propensity score matching biology.protein Female Original Article lcsh:Diseases of the digestive system. Gastroenterology Steatohepatitis Lipoproteins HDL business Cohort study |
| Zdroj: | Clinical and Molecular Hepatology, Vol 21, Iss 4, Pp 379-386 (2015) Clinical and Molecular Hepatology |
| ISSN: | 2287-285X 2287-2728 |
| DOI: | 10.3350/cmh.2015.21.4.379 |
| Popis: | Background/Aims: Vitamin E improves the biochemical profiles and liver histology in nonalcoholic steatohepatitis, but the role of vitamin E is not clearly defined in the management of nonalcoholic fatty liver disease (NAFLD) which includes both simple steatosis and steatohepatitis. Co-morbid metabolic syndrome increases the probability of steatohepatitis in NAFLD. In this study, we aimed to determine the short-term effects of vitamin E and off-treatment durability of response in a propensity-score matched cohort of NAFLD patients with metabolic syndrome. Methods: A retrospective cohort was constructed by retrieving 526 consecutive NAFLD patients from the electronic medical record data warehouse of a tertiary referral hospital in South Korea. Among them, 335 patients (63.7%) had metabolic syndrome and were eligible for vitamin E therapy. In order to assess the effect of vitamin E, propensity score matching was used by matching covariates between control patients (n=250) and patients who received vitamin E (n=85). Results: The PS-matched vitamin E group (n=58) and control group (n=58) exhibited similar baseline metabolic profiles. After 6 months of vitamin E therapy, the mean ALT levels decreased significantly compared to PS-matched control (P |
| Databáze: | OpenAIRE |
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