Controlling the Association of Adamantyl-Substituted Poly{N-[tris(hydroxymethyl)methyl]acrylamide} and aβ-Cyclodextrin/Epichlorohydrin Polymer by a Small Drug Molecule – Naproxen
| Autor: | Ladislav Šoltés, Noëlle Martine Gosselet, Bernard Sebille, Danica Mislovičová, Grigorij Kogan |
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| Rok vydání: | 2007 |
| Předmět: |
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Molecular chemistry.chemical_classification Tris Acrylamides Naproxen Adamantane beta-Cyclodextrins Bioengineering Beta-Cyclodextrins General Chemistry General Medicine Polymer Biochemistry chemistry.chemical_compound chemistry Acrylamide Polymer chemistry medicine Molecular Medicine Epichlorohydrin Hydroxymethyl Molecular Biology medicine.drug |
| Zdroj: | Chemistry & Biodiversity. 4:52-57 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.200790006 |
| Popis: | Two polymeric substances, a poly{N-[tris(hydroxymethyl)methyl]acrylamide} (THMMA) substituted with adamantyl moieties and a beta-cyclodextrin/epichlorohydrin polycondensate, formed a host-guest type complex, which resulted in the gel formation upon mixing of these two compounds at appropriate conditions. Introduction of a drug molecule, i.e., naproxen, that was able to fill the beta-cyclodextrin cavities, thus expulsing adamantyl moieties, led to disruption of such association and inhibition of gel formation. The conditions required for the association of the two polymeric components and formation of the gel, as well as the dynamics of its inhibition by addition of naproxen was established. The procedure of using solutions of two associating polymers and an appropriate drug competitor can be used at targeted viscosupplementation. |
| Databáze: | OpenAIRE |
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