Inflammatory mediator patterns in tracheal aspirate and their association with bronchopulmonary dysplasia in very low birth weight neonates
| Autor: | Xiao-Du Ping, Lou Ann S. Brown, Anne M. Fitzpatrick, Theresa W. Gauthier, Kari R. Schneibel |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty chronic lung disease behavioral disciplines and activities Gastroenterology Article premature neonate 03 medical and health sciences 0302 clinical medicine Discriminant function analysis 030225 pediatrics Internal medicine mental disorders medicine Humans Infant Very Low Birth Weight Bronchopulmonary Dysplasia business.industry Infant Newborn Discriminant Analysis Obstetrics and Gynecology medicine.disease Tracheal aspirate Infant newborn cytokines Inflammatory mediator Trachea Low birth weight 030228 respiratory system Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Female Inflammation Mediators medicine.symptom business Biomarkers Infant Premature |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/jp.2012.125 |
| Popis: | Background Alterations in inflammatory mediators are an important finding in neonates who develop bronchopulmonary dysplasia (BPD); however, there is a lack of research examining the relationship between multiple inflammatory mediators in premature neonates and the development of BPD. Objective This study investigated whether the distribution of 12 inflammatory mediators detected in the tracheal aspirate (TA) of neonates within 24 hours of birth could differentiate between neonates who did and did not develop BPD. Study Design TA samples were collected from 27 very low birth weight neonates (BPD+ =11) and the concentrations of 12 biomarkers associated with BPD were determined. Linear discriminate analysis (LDA) was used to classify neonates into two outcome groups. Result LDA based on the 12 measured biomarkers displayed a significant level of discriminant function (p=0.007). Conclusion Using linear discriminant analysis, predictive models of BPD can be generated. Our results suggest that multiple inflammatory mediators collected within 24 hours of birth may be used to classify neonates into who will and will not develop BPD. |
| Databáze: | OpenAIRE |
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