Effect of PVP K30 and/orl -Arginine on Stability Constant of Etoricoxib–HPβCD Inclusion Complex: Preparation and Characterization of Etoricoxib–HPβCD Binary System
| Autor: | Poonam Karekar, Yogesh Pore, Manali Shah, Vyas Vm, Sancheti Pp |
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| Rok vydání: | 2009 |
| Předmět: |
Magnetic Resonance Spectroscopy
Pyridines Pharmaceutical Science Arginine Excipients Etoricoxib Drug Stability X-Ray Diffraction Phase (matter) Spectroscopy Fourier Transform Infrared Drug Discovery medicine Organic chemistry Cyclooxygenase Inhibitors Sulfones Binary system Solubility Spectroscopy Dissolution Pharmacology Chemistry beta-Cyclodextrins Organic Chemistry Povidone 2-Hydroxypropyl-beta-cyclodextrin Freeze Drying Stability constants of complexes Proton NMR medicine.drug Nuclear chemistry |
| Zdroj: | Drug Development and Industrial Pharmacy. 35:118-129 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1080/03639040802220292 |
| Popis: | The effect of polyvinyl pyrrolidone (PVP) K30 and/or L-arginine on etoricoxib-HPbetaCD complex was investigated. The phase solubility profiles were classified as A(L)-type, both in absence or presence of auxiliary substances used. The apparent stability constant (K(c)) of binary complex obtained at room temperature, 371.80 +/- 2.61 M(-1), was decreased with the addition of PVP and arginine indicating no benefit of addition of auxiliary substances to promote higher complexation efficiency. Therefore, solid etoricoxib-HPbetaCD binary systems were prepared and characterized by proton nuclear magnetic resonance spectroscopy (1HNMR), X-ray powder diffractometry, Fourier transformation-infrared spectroscopy, and dissolution studies. Among all binary systems, a lyophilized product showed superior performance in enhancing dissolution of etoricoxib. |
| Databáze: | OpenAIRE |
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