Functional Roles of Female Sex Hormones and Their Nuclear Receptors in Cervical Cancer
| Autor: | Seunghan Baik, Seoung-Ae Lee, Sang-Hyuk Chung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Stromal cell
medicine.drug_class Estrogen receptor Uterine Cervical Neoplasms Cervix Uteri Biochemistry Article 03 medical and health sciences Mice 0302 clinical medicine Progesterone receptor Medicine Animals Humans Gonadal Steroid Hormones Molecular Biology Cervix 030304 developmental biology Cervical cancer 0303 health sciences business.industry Estrogens medicine.disease Disease Models Animal medicine.anatomical_structure Nuclear receptor Estrogen 030220 oncology & carcinogenesis Cancer research Female business Estrogen receptor alpha |
| Zdroj: | Essays Biochem |
| Popis: | There has been little progress for several decades in modalities to treat cervical cancer. While the cervix is a hormone-sensitive tissue, physiologic roles of estrogen receptor α (ERα), progesterone receptor (PR), and their ligands in this tissue are poorly understood. It has hampered critical assessments of data in early epidemiologic and clinical studies for cervical cancer. Experimental evidence obtained from studies using mouse models has provided new insights into the molecular mechanism of ERα and PR in cervical cancer. In a mouse model expressing human papillomavirus (HPV) oncogenes, exogenous estrogen promotes cervical cancer through stromal ERα. In the same mouse model, genetic ablation of PR promotes cervical carcinogenesis without exogenous estrogen. Medroxyprogesterone acetate, a PR-activating drug, regresses cervical cancer in the mouse model. These results support that ERα and PR play opposite roles in cervical cancer. They further support that ERα inhibition and PR activation may be translated into valuable treatment for a subset of cervical cancers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|