Distribution of hemoglobin phenotypes in four different districts of Porto Velho, Rondônia, Brazil
| Autor: | Aguinaldo Luiz Simões, W. A. Silva, M. S. Tada, A. Andrade-Casseb, V. Engracia, A. Krauze, R. M. Lafontaine |
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| Rok vydání: | 2009 |
| Předmět: |
Gene Flow
Plasmodium Hemoglobin Sickle Black People Biology White People Gene Frequency Genetics Animals Humans Allele frequency Genetics (clinical) Ecology Evolution Behavior and Systematics Sickle Hemoglobin Likelihood Functions Polymorphism Genetic Hemoglobin E Indians South American Genetic Drift Hemoglobin A Emigration and Immigration Malaria Genetics Population Phenotype Homogeneous Hemoglobin Blood bank Brazil Demography |
| Zdroj: | Human biology. 80(5) |
| ISSN: | 0018-7143 |
| Popis: | Hemoglobin profile studies have been carried out in four samples from different districts of Porto Velho (Rondonia State) in the western Amazonian region of Brazil: Candelaria, Bate Estaca, Hemeron (at the State Blood Bank), and Sao Carlos. Samples from 337 unrelated individuals were collected during medical and paramedical team visits by professionals from the Instituto de Pesquisa em Patologia Tropical and the Centro de Pesquisa em Patologias Tropicais (both research institutes in tropical diseases). The aim of this study is to assess the frequency of alleles in the hemoglobin system, mainly alleles HB*A, *S, and *E. The overall phenotype frequencies were HB A,S = 0.025, HB A,E = 0.006, and HB A,A = 0.969. Samples from the blood bank subjects and samples from the homogeneous areas of Sao Carlos and Candelaria plus Bate Estaca have a chi-square of heterogeneity of 6.383 (p = 0.041) and 8.406 (p = 0.015), respectively. The allele frequencies (HB*A = 0.984, HB*S = 0.012, and HB*E = 0.003) do not significantly differ from frequencies found in other Brazilian regions. |
| Databáze: | OpenAIRE |
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