Study of oxaliplatin penetration into ovaries of patients treated with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases of colorectal and appendiceal origin using mass spectrometry imaging
| Autor: | Sandra Mounicou, Pierre-Arnaud Faye, Olivia Sgarbura, Lucie Rebel, Marion Larroque, Cristina Leaha, Carine Arnaudguilhem, Brice Bouyssiere, Sébastien Carrere, Christine Enjalbal, François Quénet |
|---|---|
| Přispěvatelé: | Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Blanc, Sylvie |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
[CHIM.POLY] Chemical Sciences/Polymers [CHIM.ANAL] Chemical Sciences/Analytical chemistry peritoneal cancer Colorectal cancer fertility preservation Laser ablation inductively coupled plasma mass spectrometry medicine.medical_treatment Urology colorectal cancer mass spectrometry imaging Mass spectrometry imaging 03 medical and health sciences 0302 clinical medicine [CHIM.ANAL]Chemical Sciences/Analytical chemistry Internal Medicine Medicine Distribution (pharmacology) Fertility preservation 030304 developmental biology 0303 health sciences Chemotherapy [CHIM.MATE] Chemical Sciences/Material chemistry business.industry lowgrade appendiceal mucinous neoplasm (LAMN) oxaliplatin [CHIM.MATE]Chemical Sciences/Material chemistry low-grade appendiceal mucinous neoplasm (LAMN) medicine.disease 3. Good health Oxaliplatin [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry [CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry [CHIM.POLY]Chemical Sciences/Polymers 030220 oncology & carcinogenesis Hyperthermic intraperitoneal chemotherapy business medicine.drug Research Article |
| Zdroj: | Pleura and Peritoneum Pleura and peritoneum Pleura and peritoneum, Walter de Gruyter GmbH, 2021, 24 (6(2)), pp.:67-74. ⟨10.1515/pp-2020-0149⟩ Pleura and peritoneum, 2021, 24 (6(2)), pp.:67-74. ⟨10.1515/pp-2020-0149⟩ |
| ISSN: | 2364-768X 2364-7671 |
| Popis: | Objectives Platinum salts are commonly used in hyperthermic intraperitoneal chemotherapy (HIPEC) for digestive tract cancer treatment. During HIPEC with oxaliplatin for peritoneal metastases (PMs) treatment, the ovaries are directly exposed to the drug, questioning about ovarian resection and the potential impact of the drug on ovarian functionality, especially in young women of childbearing age. The goal of this work is to understand unwanted damages to the ovaries during HIPEC therapy by the determination of the concentration and distribution of platinum in ovaries in order to address its potential toxicity. Methods Mass spectrometry imaging techniques, matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP MS), were used to study the penetration of oxaliplatin in ovaries after HIPEC treatment. Results MALDI-MS allowed the localization of an oxaliplatin-derivative (m/z 456.2) at the periphery of the ovaries. The quantitative LA-ICP MS maps confirmed the localization of elemental platinum as well as in the central part of ovaries from patients who received a previous platinum salt-based chemotherapy. Conclusions LA-ICP MS images showed that platinum diffusion was extended in cases of previous systemic treatment, questioning about platinum derivatives gonado-toxicity when combining the two treatments. |
| Databáze: | OpenAIRE |
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