Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study

Autor: Kenneth W. Kross, Bernd Kremer, Rens M. G. E. van de Goor, Joey C. A. Hardy, Michel R. A. van Hooren
Přispěvatelé: Promovendi ODB, KNO, RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA AIOS Keel Neus Oorheelkunde (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Keel Neus Oorheelkunde (3), MUMC+: MA Keel Neus Oorheelkunde (9)
Rok vydání: 2019
Předmět:
Male
electronic nose
medicine.medical_treatment
Diagnostic accuracy
Disease
0302 clinical medicine
volatile organic compounds
diagnostics
Netherlands
0303 health sciences
Neoplasms
Second Primary
Middle Aged
TUMORS
Primary tumor
Breath Tests
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Female
Original Article
Radiology
RADIOTHERAPY
medicine.medical_specialty
recurrent head and neck cancer
LARYNGEAL
VOLATILE ORGANIC-COMPOUNDS
head and neck squamous cell carcinoma
DIAGNOSIS
MECHANISMS
03 medical and health sciences
otorhinolaryngologic diseases
Recurrent disease
medicine
Humans
Aged
030304 developmental biology
Electronic nose
business.industry
Head and neck cancer
Original Articles
CELL CARCINOMA
medicine.disease
Head and neck squamous-cell carcinoma
Radiation therapy
stomatognathic diseases
Otorhinolaryngology
Feasibility Studies
Neural Networks
Computer
Neoplasm Recurrence
Local
business
Zdroj: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 41(9), 2983-2990. Wiley
Head & Neck
ISSN: 1097-0347
1043-3074
DOI: 10.1002/hed.25787
Popis: Background The aim of this feasibility study was to assess the diagnostic performance of an electronic nose (e‐nose) as a noninvasive diagnostic tool in detecting locoregional recurrent and/or second (or third) primary head and neck squamous cell carcinoma (HNSCC) after curative treatment. Methods Using an e‐nose (Aeonose, The eNose Company, Zutphen, The Netherlands), breath samples were collected from patients after curative treatment of an HNSCC with a locoregional recurrence or second (or third) primary tumor (N = 20) and from patients without evidence of recurrent disease (N = 20). Analyses were performed utilizing artificial neural networking based on patterns of volatile organic compounds. Results A diagnostic accuracy of 83% was observed in differentiating follow‐up patients with locoregional recurrent or second (or third) primary HNSCC from those without evidence of disease. Conclusion This study has demonstrated the feasibility of using an e‐nose to detect locoregional recurrent and/or second (or third) primary HNSCC.
Databáze: OpenAIRE
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