Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS
| Autor: | Edmundo Pessoa de Almeida Lopes, Heloísa Ramos Lacerda, Ricardo Arraes de Alencar Ximenes, Maria de Fátima Pessoa Militão de Albuquerque, Demócrito de Barros Miranda-Filho, Ulisses Ramos Montarroyos, Magda Maruza, Bartolomeu Acioli-Santos, Carolline Araújo-Mariz |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Bacterial Diseases 0301 basic medicine Time Factors Arylamine N-Acetyltransferase Antitubercular Agents lcsh:Medicine Geographical locations 0302 clinical medicine Antiretroviral Therapy Highly Active Medicine and Health Sciences Public and Occupational Health 030212 general & internal medicine lcsh:Science Prospective cohort study Alcohol Consumption Multidisciplinary Pharmaceutics Incidence (epidemiology) Acetylation Middle Aged Vaccination and Immunization Infectious Diseases Liver Behavioral Pharmacology Female Chemical and Drug Induced Liver Injury Brazil Research Article HIV infections medicine.drug Adult medicine.medical_specialty Tuberculosis Genotype Immunology Antiretroviral Therapy Viral diseases Young Adult 03 medical and health sciences Antiviral Therapy Drug Therapy Acquired immunodeficiency syndrome (AIDS) Recreational Drug Use Internal medicine medicine Humans Highly-Active Antiretroviral Therapy Adverse effect Life Style Nutrition Pharmacology Hepatitis Acquired Immunodeficiency Syndrome business.industry Malnutrition lcsh:R Biology and Life Sciences Odds ratio South America Tropical Diseases medicine.disease Diet 030104 developmental biology Multivariate Analysis lcsh:Q Preventive Medicine People and places business Fluconazole |
| Zdroj: | PLoS ONE, Vol 11, Iss 6, p e0157725 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0157725 |
| Popis: | Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living with HIV/AIDS (PLWHA) start treatment for tuberculosis. This was a prospective cohort study with PLWHA who were monitored during the first 60 days of tuberculosis treatment in Pernambuco, Brazil. Hepatotoxicity was considered increased levels of aminotransferase, namely those that rose to three times higher than the level before initiating tuberculosis treatment, these levels being associated with symptoms of hepatitis. We conducted a multivariate logistic regression analysis and the magnitude of the associations was expressed by the odds ratio with a confidence interval of 95%. Hepatotoxicity was observed in 53 (30.6%) of the 173 patients who started tuberculosis treatment. The final multivariate logistic regression model demonstrated that the use of fluconazole, malnutrition and the subject being classified as a phenotypically slow acetylator increased the risk of hepatotoxicity significantly. The incidence of hepatotoxicity during treatment for tuberculosis in PLWHA was high. Those classified as phenotypically slow acetylators and as malnourished should be targeted for specific care to reduce the risk of hepatotoxicity during treatment for tuberculosis. The use of fluconazole should be avoided during tuberculosis treatment in PLWHA. |
| Databáze: | OpenAIRE |
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