Tumor immunity generated in the course of regression of v-src-induced sarcomas
| Autor: | Andrew W. Stoker, Michael S. Halpern, J. M. England, T. W. Wisner, Dieyn Pan |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
animal structures
Restriction Mapping Immunology Biology Virus Replication Microbiology Virus Immune system Species Specificity Immunity Virology medicine Animals Rous sarcoma virus Immunogenicity Defective Viruses DNA Neoplasm medicine.disease biology.organism_classification Genes src Avian Sarcoma Viruses Neoplasm Regression Spontaneous Cell culture Insect Science DNA Viral v-Src Sarcoma Experimental Sarcoma Chickens Research Article Plasmids |
| Zdroj: | Journal of Virology. 65:7020-7024 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.65.12.7020-7024.1991 |
| Popis: | Previous studies have indicated that the regression versus progression of v-src-DNA-induced sarcomas is dependent on chicken line. As a first step in analyzing the role of tumor immunity as a determinant of this line dependence, experiments were undertaken to ascertain whether an antisarcoma immune response is generated in the course of sarcoma growth in TK chickens, a regressor line. To assay for this response, test TK chickens in which v-src-induced wing web sarcomas had regressed, as well as control TK chickens that had not been exposed to v-src, were challenged in protocols known to yield v-src-dependent sarcoma formation and monitored for challenge sarcoma growth. Compared with the control chickens, the test chickens showed a significant resistance to the sarcomagenic challenge. These results raise the possibility that the antisarcoma response that is inducible in regressor lines, as demonstrated here in terms of a protective effect against a subsequent sarcomagenic challenge, may also underlie the regression of v-src-induced primary sarcomas. |
| Databáze: | OpenAIRE |
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